SH3BP4 Antibody (A-6): sc-393730
- SH3BP4 Antibody (A-6) is a mouse monoclonal IgG1 κ SH3BP4 antibody, cited in 7 publications, provided at 200 µg/ml
- raised against amino acids 1-193 mapping at the N-terminus of SH3BP4 of human origin
- SH3BP4 Antibody (A-6) is recommended for detection of SH3BP4 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-SH3BP4 Antibody (A-6) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for SH3BP4 Antibody (A-6) for WB applications. These reagents are now offered in bundles with SH3BP4 Antibody (A-6) (see ordering information below).
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SH3BP4 Antibody (A-6) is a mouse monoclonal IgG1 kappa light chain antibody that detects SH3BP4 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-SH3BP4 antibody (A-6) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. SH3BP4, also known as SH3-domain binding protein 4, TTP, or BOG25, is a 963 amino acid protein that plays a crucial role in cellular processes by localizing to the nucleus and exhibiting ubiquitous expression, particularly in the pancreas. SH3BP4′s structure is characterized by three Asn-Pro-Phe (NPF) motifs, an SH3 domain, a PXXP motif, a bipartite nuclear targeting signal, and a tyrosine phosphorylation site, which are essential for mediating interactions with endocytic proteins such as clathrin and dynamin. These interactions suggest SH3BP4 is involved in intracellular sorting and cell cycle regulation, highlighting SH3BP4′s importance in maintaining cellular homeostasis and facilitating proper cellular signaling. SH3BP4 is located on human chromosome 2, a region containing over 1,400 genes and accounting for nearly 8% of the human genome, underscoring SH3BP4′s potential implications in various genetic disorders, including those linked to mutations in neighboring genes.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
SH3BP4 Antibody (A-6) References:
- Cloning, chromosomal localization, and characterization of cDNA from a novel gene, SH3BP4, expressed by human corneal fibroblasts. | Dunlevy, JR., et al. 1999. Genomics. 62: 519-24. PMID: 10644451
- Nuclear and plasma membrane localization of SH3BP4 in retinal pigment epithelial cells. | Khanobdee, K., et al. 2004. Mol Vis. 10: 933-42. PMID: 15616480
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. | Hillier, LW., et al. 2005. Nature. 434: 724-31. PMID: 15815621
- TTP specifically regulates the internalization of the transferrin receptor. | Tosoni, D., et al. 2005. Cell. 123: 875-88. PMID: 16325581
- Origin of human chromosome 2: an ancestral telomere-telomere fusion. | IJdo, JW., et al. 1991. Proc Natl Acad Sci U S A. 88: 9051-5. PMID: 1924367
- MACC1 - more than metastasis? Facts and predictions about a novel gene. | Stein, U., et al. 2010. J Mol Med (Berl). 88: 11-8. PMID: 19787327
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SH3BP4 Antibody (A-6) | sc-393730 | 200 µg/ml | $322.00 | |||
SH3BP4 Antibody (A-6): m-IgG Fc BP-HRP Bundle | sc-530561 | 200 µg Ab; 10 µg BP | $361.00 | |||
SH3BP4 Antibody (A-6): m-IgGκ BP-HRP Bundle | sc-524067 | 200 µg Ab, 40 µg BP | $361.00 | |||
SH3BP4 Antibody (A-6): m-IgG1 BP-HRP Bundle | sc-544132 | 200 µg Ab; 20 µg BP | $361.00 | |||
SH3BP4 Antibody (A-6) AC | sc-393730 AC | 500 µg/ml, 25% agarose | $424.00 | |||
SH3BP4 Antibody (A-6) HRP | sc-393730 HRP | 200 µg/ml | $322.00 | |||
SH3BP4 Antibody (A-6) FITC | sc-393730 FITC | 200 µg/ml | $336.00 | |||
SH3BP4 Antibody (A-6) PE | sc-393730 PE | 200 µg/ml | $349.00 | |||
SH3BP4 Antibody (A-6) Alexa Fluor® 488 | sc-393730 AF488 | 200 µg/ml | $364.00 | |||
SH3BP4 Antibody (A-6) Alexa Fluor® 546 | sc-393730 AF546 | 200 µg/ml | $364.00 | |||
SH3BP4 Antibody (A-6) Alexa Fluor® 594 | sc-393730 AF594 | 200 µg/ml | $364.00 | |||
SH3BP4 Antibody (A-6) Alexa Fluor® 647 | sc-393730 AF647 | 200 µg/ml | $364.00 | |||
SH3BP4 Antibody (A-6) Alexa Fluor® 680 | sc-393730 AF680 | 200 µg/ml | $364.00 | |||
SH3BP4 Antibody (A-6) Alexa Fluor® 790 | sc-393730 AF790 | 200 µg/ml | $364.00 |