SH3BP4 Inhibitors
Chemical inhibitors of SH3BP4 include a variety of molecules that disrupt specific cellular processes and pathways integral to its function. Wortmannin and LY294002 are potent inhibitors of phosphoinositide 3-kinases (PI3Ks), which play a crucial role in the endocytic pathway, an area where SH3BP4 is actively involved. By inhibiting PI3K, these chemicals reduce the production of phosphatidylinositol 3-phosphate, a lipid that is essential for the endosomal trafficking function of SH3BP4. Dynasore and MiTMAB target the GTPase dynamin, which is required for the scission of clathrin-coated vesicles during endocytosis. The inhibition of dynamin prevents the proper formation and trafficking of vesicles, thereby inhibiting the role of SH3BP4 in these processes.
Moreover, microtubule-targeting agents like Paclitaxel (Taxol) and Nocodazole affect the dynamics of microtubules, which are critical for the trafficking and signaling functions that SH3BP4 is known to be associated with. Paclitaxel (Taxol) stabilizes microtubules, while Nocodazole disrupts microtubule polymerization, both leading to an inhibition of SH3BP4 function by interfering with its ability to navigate along these cellular "highways." Further inhibiting endocytic trafficking, Pitstop 2 and Chlorpromazine block clathrin-mediated endocytosis, thus impeding SH3BP4's role in clathrin-coated vesicle formation. Endosidin 9 disrupts ARF-GEF interactions with ARF1, affecting the vesicle trafficking required for SH3BP4's sorting function, while ML141 selectively inhibits Cdc42 GTPase, impairing the actin cytoskeleton rearrangement needed for efficient endocytosis where SH3BP4 operates. SecinH3 targets ARF GTPase exchange factors, inhibiting endocytic and signaling pathways that involve SH3BP4. Lastly, Ipatasertib, an AKT inhibitor, disrupts downstream signaling processes that involve SH3BP4, effectively inhibiting its role in cellular signaling and trafficking.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin is a specific inhibitor of phosphoinositide 3-kinases (PI3Ks). SH3BP4 is known to interact with PI3K-regulated pathways, and inhibition of PI3K by Wortmannin can lead to reduced activity of SH3BP4 by preventing its association with PI3K-dependent endocytic vesicle trafficking. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is another inhibitor of PI3K. By inhibiting PI3K, LY294002 can reduce SH3BP4 function by limiting the phosphatidylinositol 3-phosphate (PI3P) levels necessary for its endosomal sorting functions. | ||||||
Dynamin Inhibitor I, Dynasore | 304448-55-3 | sc-202592 | 10 mg | $89.00 | 44 | |
Dynasore inhibits dynamin, a GTPase involved in endocytosis. As SH3BP4 has a role in endocytic trafficking, the inhibition of dynamin by Dynasore can lead to the functional inhibition of SH3BP4 by preventing the vesicle scission from the plasma membrane where SH3BP4 might be involved. | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $41.00 $74.00 $221.00 $247.00 $738.00 $1220.00 | 39 | |
Paclitaxel stabilizes microtubules and can inhibit their disassembly. By stabilizing microtubules, Paclitaxel can inhibit SH3BP4 function by disrupting microtubule dynamics that are essential for its role in endocytic trafficking and signal transduction. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $59.00 $85.00 $143.00 $247.00 | 38 | |
Nocodazole disrupts microtubules by binding to beta-tubulin and inhibiting its polymerization. Disruption of microtubules by Nocodazole can lead to the inhibition of SH3BP4's role in microtubule-dependent trafficking processes. | ||||||
Pitstop 2 | 1419320-73-2 | sc-507418 | 10 mg | $360.00 | ||
Pitstop 2 inhibits clathrin-mediated endocytosis by targeting the clathrin terminal domain. Inhibition of this pathway can lead to the functional inhibition of SH3BP4 by impeding the formation of clathrin-coated vesicles involved in its trafficking functions. | ||||||
Chlorpromazine | 50-53-3 | sc-357313 sc-357313A | 5 g 25 g | $61.00 $110.00 | 21 | |
Chlorpromazine can block clathrin-mediated endocytosis by preventing the assembly of clathrin and adaptor proteins. This blockage can inhibit SH3BP4 function by disrupting its associated endocytic pathways. | ||||||
ML 141 | 71203-35-5 | sc-362768 sc-362768A | 5 mg 25 mg | $137.00 $512.00 | 7 | |
ML141 is a potent and selective inhibitor of Cdc42 GTPase. By inhibiting Cdc42, ML141 can impair actin cytoskeleton rearrangement which is essential for the endocytosis process where SH3BP4 is involved, leading to its functional inhibition. | ||||||
SecinH3 | 853625-60-2 | sc-203260 | 5 mg | $278.00 | 6 | |
SecinH3 inhibits cytohesins, which are ARF GTPase exchange factors. Inhibition of cytohesins can impair endocytic and signaling pathways where SH3BP4 is implicated, thus inhibiting its function. | ||||||
(2S)-2-(4-Chlorophenyl)-1-[4-[(5R,7R)-6,7-dihydro-7-hydroxy-5-methyl-5H-cyclopentapyrimidin-4-yl]-1-piperazinyl]-3-[(1-methylethyl)amino]-1-propanone | sc-501166 | 5 mg | $540.00 | |||
Ipatasertib is a potent inhibitor of AKT, a kinase involved in various signaling pathways. By inhibiting AKT, Ipatasertib can inhibit downstream signaling processes that involve SH3BP4, thereby inhibiting its cellular functions related to signaling and trafficking. | ||||||