SH3BGRL Antibody (E-5): sc-377108

SH3BGRL Antibody (E-5) is a mouse monoclonal IgG3 kappa light chain antibody that detects SH3BGRL protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-SH3BGRL antibody (E-5) is available as the non-conjugated form. SH3BGRL (clone E-5) antibody recognizes SH3 domain binding glutamic acid-rich protein like, which consists of 114 amino acids and is ubiquitously expressed, playing a crucial role in cellular signaling pathways. SH3BGRL monoclonal antibody (E-5) targets a protein that′s particularly important due to its involvement in the regulation of protein interactions through its SH3 domain, which facilitates binding to proline-rich motifs in target proteins. This interaction is vital for various cellular processes, including cytoskeletal organization, cell proliferation, and apoptosis, making SH3BGRL essential for maintaining cellular homeostasis and responding to external stimuli. The gene encoding SH3BGRL is located on the X chromosome, which is essential for sex determination and is associated with several genetic conditions when abnormalities occur. With broad species reactivity and multiple applications, anti-SH3BGRL antibody (E-5) serves as an invaluable tool for researchers studying the intricate roles of SH3BGRL in health and disease.

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SH3BGRL Antibody (E-5) References:

1. Identification, mapping, and genomic structure of a novel X-chromosomal human gene (SMPX) encoding a small muscular protein.  |  Patzak, D., et al. 1999. Hum Genet. 105: 506-12. PMID: 10598820
2. Identification of a novel stretch-responsive skeletal muscle gene (Smpx).  |  Kemp, TJ., et al. 2001. Genomics. 72: 260-71. PMID: 11401441
3. Features of Turner's syndrome in women with polycystic ovaries.  |  Givens, JR., et al. 1975. Obstet Gynecol. 45: 619-24. PMID: 1143721
4. Overall DNA methylation and chromatin structure of normal and abnormal X chromosomes.  |  Bernardino-Sgherri, J., et al. 2002. Cytogenet Genome Res. 99: 85-91. PMID: 12900549
5. Dystrophin and mutations: one gene, several proteins, multiple phenotypes.  |  Muntoni, F., et al. 2003. Lancet Neurol. 2: 731-40. PMID: 14636778
6. Heart morphogenesis is not affected by overexpression of the Sh3bgr gene mapping to the Down syndrome heart critical region.  |  Sandri, C., et al. 2004. Hum Genet. 114: 517-9. PMID: 14767758
7. The molecular basis of variation in human color vision.  |  Deeb, SS. 2005. Clin Genet. 67: 369-77. PMID: 15811001
8. Novel form of a single X-linked visual pigment gene in a unique dichromatic color-vision defect.  |  Hayashi, T., et al. 2006. Vis Neurosci. 23: 411-7. PMID: 16961974
9. Sensing X chromosome pairs before X inactivation via a novel X-pairing region of the Xic.  |  Augui, S., et al. 2007. Science. 318: 1632-6. PMID: 18063799
10. Signal transducer and activator of transcription 2 (STAT2) metabolism coupling postmitotic outgrowth to visual and sound perception network in human left cerebrum by biocomputation.  |  Wang, L., et al. 2012. J Mol Neurosci. 47: 649-58. PMID: 22219046
11. Prevalence of chromosomal rearrangements involving non-ETS genes in prostate cancer.  |  Kluth, M., et al. 2015. Int J Oncol. 46: 1637-42. PMID: 25625310
12. Identification and characterization of a new human gene encoding a small protein with high homology to the proline-rich region of the SH3BGR gene.  |  Egeo, A., et al. 1998. Biochem Biophys Res Commun. 247: 302-6. PMID: 9642120

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-SH3BGRL Antibody (E-5) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-SH3BGRL Antibody (E-5) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

SH3BGRL Antibody (E-5) Specifications

Alternate Product Name: SH3BGRL

Product Clone Name: E-5

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₃ kappa light chain

Amino Acids: 41-75

Epitope Target: SH3BGRL

Epitope Species: human

Product Reactivity/Detection: SH3BGRL

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: equine and bovine

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₃ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for SH3BGRL Antibody (E-5): P: Blocking Peptide