SH2D1A Antibody (1D12): sc-53859
- SH2D1A Antibody (1D12) is a rat monoclonal IgG2a, cited in 3 publications, provided at 200 µg/ml
- raised against full length SH2D1A of human origin
- recommended for detection of SH2D1A of human origin by WB, IP, FCM and ELISA
- available conjugated to either phycoerythrin or FITC for IF, IHC(P) and FCM
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for SH2D1A Antibody (1D12). This work is in progress.
SH2D1A Antibody (1D12) is a rat monoclonal IgG2a antibody that detects SH2D1A in human samples through applications such as western blotting (WB), immunoprecipitation (IP), flow cytometry (FCM), and enzyme-linked immunosorbent assay (ELISA). SH2D1A, also known as SH2 domain protein 1A, SAP, and CD150/SLAM (signaling lymphocyte activation molecule)-associated protein, plays a crucial role in modulating immune responses by influencing signaling pathways involving SLAM molecules at the interface between T and B cells. SH2D1A blocks the recruitment of tyrosine phosphatase SHP2 to the phosphorylated cytoplasmic domain of SLAM, facilitating the expansion of activated T cells during immune responses and promoting interferon-γ production. Structurally, SH2D1A is a hydrophilic protein composed of 128 amino acids, exhibiting 96% homology with its mouse counterpart in both SH2 and tail domains. SH2D1A is expressed in all major subsets of T cells, including CD4+, CD45RO+, CD45RA+, and CD8+, but is absent in B cells. Additionally, SH2D1A interacts with several cell-surface receptors, including SLAM (CD150), CD84, CD229 (LY9), and CD244 (2B4), through its SH2 domain, highlighting its importance in T cell signaling and immune regulation.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SH2D1A Antibody (1D12) | sc-53859 | 200 µg/ml | $322.00 | |||
SH2D1A Antibody (1D12) FITC | sc-53859 FITC | 200 µg/ml | $336.00 | |||
SH2D1A Antibody (1D12) PE | sc-53859 PE | 200 µg/ml | $349.00 |