SG2NA Antibody (S68): sc-13562
- SG2NA Antibody (S68) is a mouse monoclonal IgG1 κ SG2NA antibody, cited in 5 publications, provided at 100 µl ascites
- raised against a synthetic peptide corresponding to amino acids 227-243 of SG2NA of human origin
- recommended for detection of SG2NA of mouse, rat, human and monkey origin by WB and IP; non cross-reactive with striatin or other PP2A subunits
- m-IgG Fc BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for SG2NA Antibody (S68) for WB applications. These reagents are now offered in bundles with SG2NA Antibody (S68) (see ordering information below).
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SG2NA Antibody (S68) is a mouse monoclonal IgG1 kappa light chain antibody that detects SG2NA protein of mouse, rat, human, and monkey origin by western blotting (WB) and immunoprecipitation (IP). Anti-SG2NA antibody (S68) is available as a non-conjugated monoclonal isotype antibody. SG2NA, a member of the striatin family, plays a crucial role in cellular signaling and is involved in the regulation of various physiological processes, including neuronal development and muscle function. SG2NA is primarily expressed in brain and muscle tissues, where SG2NA participates in forming protein complexes that mediate interactions with calmodulin in the presence of calcium ions. This interaction modulates calcium-dependent signaling pathways, essential for processes such as synaptic plasticity and muscle contraction. SG2NA maintains neuronal polarity and dendritic growth, as SG2NA downregulation can lead to impaired neuronal development and altered locomotor activity in animal models. Along with striatin and zinedin family members, SG2NA exhibits a multimodular structure characterized by WD repeat domains, which facilitate protein-protein interactions, underscoring SG2NA′s significance in cellular communication and signaling networks.
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SG2NA Antibody (S68) References:
- Down-regulation of striatin, a neuronal calmodulin-binding protein, impairs rat locomotor activity. | Bartoli, M., et al. 1999. J Neurobiol. 40: 234-43. PMID: 10413453
- Zinedin, SG2NA, and striatin are calmodulin-binding, WD repeat proteins principally expressed in the brain. | Castets, F., et al. 2000. J Biol Chem. 275: 19970-7. PMID: 10748158
- Molecular cloning and characterization of phocein, a protein found from the Golgi complex to dendritic spines. | Baillat, G., et al. 2001. Mol Biol Cell. 12: 663-73. PMID: 11251078
- Expression and distribution of phocein and members of the striatin family in neurones of rat peripheral ganglia. | Blondeau, C., et al. 2003. Histochem Cell Biol. 119: 131-8. PMID: 12610732
- Immunogold localization of phocein in dendritic spines. | Haeberlé, AM., et al. 2006. J Comp Neurol. 495: 336-50. PMID: 16440294
- Targeting of proteins of the striatin family to dendritic spines: role of the coiled-coil domain. | Gaillard, S., et al. 2006. Traffic. 7: 74-84. PMID: 16445688
- A novel calmodulin-binding protein, belonging to the WD-repeat family, is localized in dendrites of a subset of CNS neurons. | Castets, F., et al. 1996. J Cell Biol. 134: 1051-62. PMID: 8769426
- Relationships between striatin-containing neurons and cortical or thalamic afferent fibres in the rat striatum. An ultrastructural study by dual labelling. | Kachidian, P., et al. 1998. Neuroscience. 85: 111-22. PMID: 9607707
- Distribution of striatin, a newly identified calmodulin-binding protein in the rat brain: an in situ hybridization and immunocytochemical study. | Salin, P., et al. 1998. J Comp Neurol. 397: 41-59. PMID: 9671278
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SG2NA Antibody (S68) | sc-13562 | 100 µl ascites | $322.00 | |||
SG2NA Antibody (S68): m-IgG Fc BP-HRP Bundle | sc-536577 | 100 µl Ab; 10 µg BP | $361.00 | |||
SG2NA Antibody (S68): m-IgGκ BP-HRP Bundle | sc-533728 | 100 µl Ab; 40 µg BP | $361.00 |