SF3B3 Antibody (D-2): sc-514034

SF3B3 Antibody (D-2) is a mouse monoclonal IgG2a antibody that detects SF3B3 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). SF3B3 is a critical component of the U2 small nuclear ribonucleoprotein (snRNP) complex, which is essential for the assembly of the spliceosome, a molecular machine responsible for the splicing of pre-mRNA. SF3B3 facilitates the recognition of splice sites, ensuring accurate mRNA processing and gene expression regulation. SF3B3 interacts with other spliceosomal proteins, including SAP 145 and SAP 155, forming a complex that is crucial for the stability and functionality of the spliceosome. The interaction between SF3B3 and these proteins is essential for the recruitment of U2 snRNP to the branch site of pre-mRNA, highlighting SF3B3′s importance in the splicing process. Anti-SF3B3 antibody (D-2) effectively detects SF3B3 across various species, making this antibody an invaluable tool for researchers studying RNA splicing mechanisms and their implications in cellular function and disease.

The preferred SF3B3 antibody is SF3B3 Antibody (B-4): sc-398670.