SerRS Antibody (C-2): sc-271032
- SerRS Antibody (C-2) is a mouse monoclonal IgG2b κ SerRS antibody, cited in 1 publications, provided at 200 µg/ml
- raised against amino acids 57-355 mapping within an internal region of SerRS of human origin
- SerRS Antibody (C-2) is recommended for detection of SerRS of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-SerRS Antibody (C-2) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for SerRS Antibody (C-2) for WB applications. These reagents are now offered in bundles with SerRS Antibody (C-2) (see ordering information below).
QUICK LINKS
SerRS Antibody (C-2) is a mouse monoclonal IgG2b kappa light chain antibody that detects SerRS protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-SerRS antibody (C-2) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. SerRS, also known as seryl-tRNA synthetase, plays a crucial role in protein synthesis by catalyzing the aminoacylation of tRNASer with serine, thereby ensuring accurate translation of genetic information into functional proteins. SerRS (C-2) monoclonal antibody recognizes a cytoplasmic enzyme that exists as a homodimer, featuring a core catalytic domain and a tRNA-binding domain essential for function. SerRS recognizes and serylates both tRNASer and tRNASec, involved in selenocysteine biosynthesis, a critical amino acid for antioxidant defense and redox regulation. anti-SerRS antibody (C-2) serves as a valuable tool for researchers studying protein synthesis and post-translational modifications, particularly in contexts involving cellular homeostasis and oxidative stress responses.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
SerRS Antibody (C-2) References:
- Characterization and tRNA recognition of mammalian mitochondrial seryl-tRNA synthetase. | Yokogawa, T., et al. 2000. J Biol Chem. 275: 19913-20. PMID: 10764807
- Antibodies against c-Jun N-terminal peptide cross-react with neo-epitopes emerging after caspase-mediated proteolysis during apoptosis. | Casas, C., et al. 2001. J Neurochem. 77: 904-15. PMID: 11331419
- Aminoacyl-tRNA surveillance by EF-Tu in mammalian mitochondria. | Nagao, A., et al. 2007. Nucleic Acids Symp Ser (Oxf). 41-2. PMID: 18029576
- Divergence of selenocysteine tRNA recognition by archaeal and eukaryotic O-phosphoseryl-tRNASec kinase. | Sherrer, RL., et al. 2008. Nucleic Acids Res. 36: 1871-80. PMID: 18267971
- Mammalian seryl-tRNA synthetase associates with mRNA in vivo and has homology to elongation factor 1 alpha. | Miseta, A., et al. 1991. J Biol Chem. 266: 19158-61. PMID: 1918033
- The long extra arms of human tRNA((Ser)Sec) and tRNA(Ser) function as major identify elements for serylation in an orientation-dependent, but not sequence-specific manner. | Wu, XQ. and Gross, HJ. 1993. Nucleic Acids Res. 21: 5589-94. PMID: 8284203
- Genomic organization, cDNA sequence, bacterial expression, and purification of human seryl-tRNA synthase. | Vincent, C., et al. 1997. Eur J Biochem. 250: 77-84. PMID: 9431993
- Minimal tRNA(Ser) and tRNA(Sec) substrates for human seryl-tRNA synthetase: contribution of tRNA domains to serylation and tertiary structure. | Heckl, M., et al. 1998. FEBS Lett. 427: 315-9. PMID: 9637248
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SerRS Antibody (C-2) | sc-271032 | 200 µg/ml | $322.00 | |||
SerRS Antibody (C-2): m-IgGκ BP-HRP Bundle | sc-521821 | 200 µg Ab, 40 µg BP | $361.00 | |||
SerRS Antibody (C-2): m-IgG2b BP-HRP Bundle | sc-548973 | 200 µg Ab; 10 µg BP | $361.00 | |||
SerRS Antibody (C-2) AC | sc-271032 AC | 500 µg/ml, 25% agarose | $424.00 | |||
SerRS Antibody (C-2) HRP | sc-271032 HRP | 200 µg/ml | $322.00 | |||
SerRS Antibody (C-2) FITC | sc-271032 FITC | 200 µg/ml | $336.00 | |||
SerRS Antibody (C-2) PE | sc-271032 PE | 200 µg/ml | $349.00 | |||
SerRS Antibody (C-2) Alexa Fluor® 488 | sc-271032 AF488 | 200 µg/ml | $364.00 | |||
SerRS Antibody (C-2) Alexa Fluor® 546 | sc-271032 AF546 | 200 µg/ml | $364.00 | |||
SerRS Antibody (C-2) Alexa Fluor® 594 | sc-271032 AF594 | 200 µg/ml | $364.00 | |||
SerRS Antibody (C-2) Alexa Fluor® 647 | sc-271032 AF647 | 200 µg/ml | $364.00 | |||
SerRS Antibody (C-2) Alexa Fluor® 680 | sc-271032 AF680 | 200 µg/ml | $364.00 | |||
SerRS Antibody (C-2) Alexa Fluor® 790 | sc-271032 AF790 | 200 µg/ml | $364.00 |