SerpinB6 Antibody (G-5): sc-398463

SerpinB6 Antibody (G-5) is a mouse monoclonal IgG2a antibody that detects SerpinB6 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). SerpinB6, also known as protease inhibitor 6 (PI-6) in humans and Spi3 in mice, plays a crucial role in regulating proteolytic activity within the cytoplasm. Unlike many serpins that are secreted and function extracellularly, SerpinB6 is predominantly found in the cytoplasm of various cell types, including capillary endothelial cells, platelets, epithelial cells, monocytes, and granulocytes. This unique localization allows SerpinB6 to effectively inhibit intracellular proteases, maintaining cellular homeostasis and protecting against unwanted proteolytic activity. SerpinB6 forms stable complexes with arginine-selective proteases such as human kallikrein 2 (hK2) and cathepsin G, which are involved in various physiological processes, including inflammation and tissue remodeling. The ability of SerpinB6 to modulate these proteases highlights the importance in both normal cellular function and potential pathological conditions. anti-SerpinB6 antibody (G-5) serves as an essential tool for researchers studying proteolytic pathways and their implications in health and disease.

The preferred SerpinB6 antibody is SerpinB6 Antibody (F-5): sc-374535.