SERCA2 Antibody (F-1): sc-376235

SERCA2 Antibody (F-1) is a mouse monoclonal IgG1 kappa light chain antibody that detects SERCA2 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). SERCA2 Antibody (F-1) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. SERCA2, a member of the sarcoplasmic or endoplasmic reticulum calcium ATPase family, plays a crucial role in calcium homeostasis by mediating the uptake of Ca2+ into the sarcoplasmic reticulum, which is essential for muscle contraction and relaxation. Anti-SERCA2 antibody (F-1) helps researchers study cardiac contractility regulation through intracellular calcium levels, influencing heartbeat strength and rhythm. SERCA2 exists in two isoforms: SERCA2a, predominantly expressed in type I (slow) skeletal muscle, cardiac, and smooth muscle, and SERCA2b, found in all cell types. The differential expression and tissue-specific processing of SERCA2 are critical for diverse physiological roles, making SERCA2 (F-1) monoclonal antibody an invaluable tool for studying calcium signaling and muscle physiology in various research contexts.

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SERCA2 Antibody (F-1) References:

1. SERCA2 regulates non-CF and CF airway epithelial cell response to ozone.  |  Ahmad, S., et al. 2011. PLoS One. 6: e27451. PMID: 22096575
2. SERCA2 Haploinsufficiency in a Mouse Model of Darier Disease Causes a Selective Predisposition to Heart Failure.  |  Prasad, V., et al. 2015. Biomed Res Int. 2015: 251598. PMID: 26064889
3. HIF-1 regulation of miR-29c impairs SERCA2 expression and cardiac contractility.  |  Williams, AL., et al. 2019. Am J Physiol Heart Circ Physiol. 316: H554-H565. PMID: 30575439
4. LncEDCH1 improves mitochondrial function to reduce muscle atrophy by interacting with SERCA2.  |  Cai, B., et al. 2022. Mol Ther Nucleic Acids. 27: 319-334. PMID: 35024244
5. Adipocyte-specific ablation of the Ca2+ pump SERCA2 impairs whole-body metabolic function and reveals the diverse metabolic flexibility of white and brown adipose tissue.  |  Bauzá-Thorbrügge, M., et al. 2022. Mol Metab. 63: 101535. PMID: 35760318
6. Remote ischemic postconditioning alleviates cerebral ischemic injury through SERCA2/endoplasmic reticulum stress-mediated apoptosis.  |  Chen, W., et al. 2024. Microsc Res Tech. 87: 424-433. PMID: 37897375
7. Expression of two isoforms of the third sarco/endoplasmic reticulum Ca2+ ATPase (SERCA3) in platelets. Possible recognition of the SERCA3b isoform by the PL/IM430 monoclonal antibody.  |  Bobe, R., et al. 1998. FEBS Lett. 423: 259-64. PMID: 9512369
8. Calcium ATPase and respiratory muscle function.  |  Aubier, M. and Viires, N. 1998. Eur Respir J. 11: 758-66. PMID: 9596133
9. Characterization of the 3' end of the mouse SERCA 3 gene and tissue distribution of mRNA spliced variants.  |  Ozog, A., et al. 1998. FEBS Lett. 427: 349-52. PMID: 9637255
10. Enhanced myocardial contractility and increased Ca2+ transport function in transgenic hearts expressing the fast-twitch skeletal muscle sarcoplasmic reticulum Ca2+-ATPase.  |  Loukianov, E., et al. 1998. Circ Res. 83: 889-97. PMID: 9797337
11. Cellular distribution of Ca2+ pumps and Ca2+ release channels in rat cardiac hypertrophy induced by aortic stenosis.  |  Anger, M., et al. 1998. Circulation. 98: 2477-86. PMID: 9832495
12. Functional characterization of alternatively spliced human SERCA3 transcripts.  |  Poch, E., et al. 1998. Am J Physiol. 275: C1449-58. PMID: 9843705

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-SERCA2 Antibody (F-1) has 53 citations in a variety of scientific publications.

Primary antibodies like Anti-SERCA2 Antibody (F-1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

SERCA2 Antibody (F-1) Specifications

Alternate Product Name: SERCA2

Product Clone Name: F-1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 2-29

Epitope Target: SERCA2

Epitope Species: human

Product Reactivity/Detection: SERCA2

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: equine, canine, bovine and porcine

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 53 citations in various scientific publications

Available Conjugates/Forms for SERCA2 Antibody (F-1): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin