Date published: 2026-1-22

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SERCA Antibodies

Santa Cruz Biotechnology supplies a comprehensive collection of SERCA monoclonal antibodies for advanced research in cellular calcium regulation. SERCA Antibodies are compatible with multiple techniques, including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), flow cytometry (FCM), and enzyme-linked immunosorbent assay (ELISA). The Sarcoplasmic Reticulum Ca²⁺-ATPase (SERCA) plays a crucial role in muscle contraction and relaxation by regulating calcium ion levels within cells. Proper functioning of SERCA is essential for maintaining calcium homeostasis, which is vital for various physiological processes, including cardiac and skeletal muscle function. Dysregulation of SERCA has been implicated in several diseases, including heart failure, muscular dystrophy, and diabetes. SERCA monoclonal antibodies enable researchers to explore calcium transport mechanisms across cellular membranes. Understanding SERCA function and regulation contributes to the development of therapeutic strategies for calcium-related disorders. Investigating SERCA activity patterns helps reveal new insights into muscle physiology and pathology. SERCA monoclonal antibodies from Santa Cruz Biotechnology support researchers worldwide in advancing our understanding of calcium signaling pathways and their impact on human health.

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SERCA Antibodies

Empty Table HeaderProduct NameCATALOG #ISOTYPEEPITOPEAPPLICATIONSSpeciesCitationsRATING

SERCA1 Antibody (A-6)

sc-515162mouse IgG1 λ851-874 (h)WB, IP, IF, IHC(P), ELISAm, r, h
4
(4)

SERCA1 Antibody (IIH11)

sc-53011mouse IgG1 κFL (rabbit)WB, IP, IFm, r, rabbit, canine and guinea pig
3
(2)

SERCA1 Antibody (VE121G9)

sc-58287mouse IgG1 κ(rabbit)WB, IP, IFm, r, h, rabbit and canine
4
(2)

SERCA1 Antibody (4i352)

sc-73017mouse IgG1 κFL (rabbit)WB, IP, IFm, r, rabbit and canine

new

(1)

SERCA1 Antibody (4i390)

sc-73020mouse IgG1 κ(rabbit)WB, IP, IFm, r, h, rabbit and canine

new

(1)

SERCA1 Antibody (6D138)

sc-73019mouse IgG1 κ(rabbit)WB, IP, IFm, r, h, rabbit and canine

new

(1)

SERCA1 Antibody (6D139)

sc-73018mouse IgG1 κFL (rabbit)WB, IP, IFm, r, rabbit and canine

new

(1)

SERCA1 Antibody (G-8)

sc-365098mouse IgG1 κN-terminal (h)WB, IP, IF, ELISAm, r, h
1
(1)

SERCA1/2/3 Antibody (B-7)

sc-271669mouse IgG1 κ1-300 (h)WB, IP, IF, ELISAm, r, h
12
(5)

SERCA2 Antibody (F-1)

sc-376235mouse IgG1 κ2-29 (h)WB, IP, IF, IHC(P), ELISAm, r, h
51
(20)

SERCA2 Antibody (IID8)

sc-53010mouse IgG1 κ(canine)WB, IP, IF, IHC(P)m, r, h
24
(7)

SERCA2 Antibody (4i351)

sc-73022mouse IgG1 κFL (canine)WB, IP, IFm, r, h
9
(3)

SERCA3 Antibody (PL/IM430)

sc-81759mouse IgG1 κ(h)WB, IP, IFm, r, h
7
(9)

SERCA CRISPR Knockout, HDR and Double Nickase Plasmids

Empty Table HeaderProduct NameCATALOG #SpeciesAPPLICATIONSMARKERCitationsRATING

SERCA1 Double Nickase Plasmid (h)

sc-401416-NIChGene KnockoutPuromycin0
(0)

SERCA1 Double Nickase Plasmid (h2)

sc-401416-NIC-2hGene KnockoutPuromycin0
(0)

SERCA2 CRISPR/Cas9 KO Plasmid (h2)

sc-400417-KO-2hGene KnockoutGFP0
(0)

SERCA2 HDR Plasmid (h2)

sc-400417-HDR-2hHomology Directed RepairPuromycin0
(0)

SERCA2 Double Nickase Plasmid (h)

sc-400417-NIChGene KnockoutPuromycin0
(0)

SERCA2 Double Nickase Plasmid (h2)

sc-400417-NIC-2hGene KnockoutPuromycin0
(0)

SERCA3 CRISPR/Cas9 KO Plasmid (h)

sc-402840hGene KnockoutGFP0
(0)

SERCA3 HDR Plasmid (h)

sc-402840-HDRhHomology Directed RepairPuromycin0
(0)

SERCA3 Double Nickase Plasmid (h)

sc-402840-NIChGene KnockoutPuromycin0
(0)

SERCA3 Double Nickase Plasmid (h2)

sc-402840-NIC-2hGene KnockoutPuromycin0
(0)

SERCA CRISPR Activation Products

Empty Table HeaderProduct NameCATALOG #SpeciesAPPLICATIONSMARKERCitationsRATING

SERCA2 CRISPR Activation Plasmid (h)

sc-400417-ACThGene ActivationPuro, Blast, Hygro0
(0)

SERCA3 CRISPR Activation Plasmid (h)

sc-402840-ACThGene ActivationPuro, Blast, Hygro0
(0)

SERCA3 CRISPR Activation Plasmid (h2)

sc-402840-ACT-2hGene ActivationPuro, Blast, Hygro0
(0)

SERCA siRNA, shRNA Plasmid and shRNA Lentiviral Particle Gene Silencers

Empty Table HeaderProduct NameCATALOG #SpeciesAPPLICATIONSMARKERCitationsRATING

SERCA1 siRNA (h)

sc-36482hGene SilencingN/A0
(0)

SERCA1 shRNA Plasmid (h)

sc-36482-SHhGene SilencingPuromycin0
(0)

SERCA1 shRNA (h) Lentiviral Particles

sc-36482-VhGene SilencingPuromycin0
(0)

SERCA1 siRNA (m)

sc-36483mGene SilencingN/A0
(0)

SERCA1 shRNA Plasmid (m)

sc-36483-SHmGene SilencingPuromycin0
(0)

SERCA1 shRNA (m) Lentiviral Particles

sc-36483-VmGene SilencingPuromycin0
(0)

SERCA2 siRNA (h)

sc-36484hGene SilencingN/A
5
(0)

SERCA2 shRNA Plasmid (h)

sc-36484-SHhGene SilencingPuromycin
5
(0)

SERCA2 shRNA (h) Lentiviral Particles

sc-36484-VhGene SilencingPuromycin
5
(0)

SERCA2 siRNA (m)

sc-36485mGene SilencingN/A
3
(0)

SERCA2 shRNA Plasmid (m)

sc-36485-SHmGene SilencingPuromycin
3
(0)

SERCA2 shRNA (m) Lentiviral Particles

sc-36485-VmGene SilencingPuromycin
3
(0)

SERCA3 siRNA (h)

sc-41295hGene SilencingN/A
2
(1)

SERCA3 shRNA Plasmid (h)

sc-41295-SHhGene SilencingPuromycin
2
(1)

SERCA3 shRNA (h) Lentiviral Particles

sc-41295-VhGene SilencingPuromycin
2
(1)

SERCA3 siRNA (m)

sc-41296mGene SilencingN/A0
(0)

SERCA3 shRNA Plasmid (m)

sc-41296-SHmGene SilencingPuromycin0
(0)

SERCA3 shRNA (m) Lentiviral Particles

sc-41296-VmGene SilencingPuromycin0
(0)