SERCA1 Antibody (6D139): sc-73018

SERCA1 Antibody (6D139) is a mouse monoclonal IgG1 antibody that detects SERCA1 in mouse, rat, rabbit, and canine samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). SERCA1, a member of the sarcoplasmic or endoplasmic reticulum calcium ATPase family, plays a crucial role in muscle physiology by mediating the uptake of calcium ions into the sarcoplasmic reticulum, which is essential for muscle contraction and relaxation. SERCA1 is predominantly expressed in type II (fast) skeletal muscle, where SERCA1 helps maintain low cytoplasmic calcium concentrations, thereby facilitating rapid muscle responses. Proper functioning of SERCA1 is vital for muscle performance, as SERCA1 ensures efficient calcium sequestration, allowing for muscle relaxation after contraction. Dysregulation of SERCA1 can lead to impaired muscle function and has been implicated in various muscle-related disorders. Anti-SERCA1 antibody (6D139) serves as an invaluable tool for researchers studying calcium signaling and muscle physiology, providing insights into the mechanisms underlying muscle contraction and relaxation.

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SERCA1 Antibody (6D139) References:

1. Comparison of SERCA1 and SERCA2a expressed in COS-1 cells and cardiac myocytes.  |  Sumbilla, C., et al. 1999. Am J Physiol. 277: H2381-91. PMID: 10600859
2. Identification of weight-bearing-responsive elements in the skeletal muscle sarco(endo)plasmic reticulum Ca2+ ATPase (SERCA1) gene.  |  Mitchell-Felton, H., et al. 2000. J Biol Chem. 275: 23005-11. PMID: 10811813
3. Method-related effects of adenovirus-mediated LacZ and SERCA1 gene transfer on contractile behavior of cultured failing human cardiomyocytes.  |  Weisser-Thomas, J., et al. 2005. J Pharmacol Toxicol Methods. 51: 91-103. PMID: 15767202
4. Solid-state NMR and functional measurements indicate that the conserved tyrosine residues of sarcolipin are involved directly in the inhibition of SERCA1.  |  Hughes, E., et al. 2007. J Biol Chem. 282: 26603-13. PMID: 17616528
5. Induction of Ca2+ signal mediated apoptosis and alteration of IP3R1 and SERCA1 expression levels by stress hormone in differentiating C2C12 myoblasts.  |  Chai, J., et al. 2010. Gen Comp Endocrinol. 166: 241-9. PMID: 19723525
6. Immunohistochemical evidence for expression of fast-twitch type sarco(endo)plasmic reticulum Ca2+ ATPase (SERCA1) in German shepherd dogs with dilated cardiomyopathy myocardium.  |  Summerfield, N., et al. 2010. J Vet Cardiol. 12: 17-23. PMID: 20188644
7. The Ca2+-ATPase (SERCA1) is inhibited by 4-aminoquinoline derivatives through interference with catalytic activation by Ca2+, whereas the ATPase E2 state remains functional.  |  Bartolommei, G., et al. 2011. J Biol Chem. 286: 38383-38389. PMID: 21914795
8. Relative sarcolipin (SLN) and sarcoplasmic reticulum Ca2+ ATPase (SERCA1) transcripts levels in closely related endothermic and ectothermic scombrid fishes: Implications for molecular basis of futile calcium cycle non-shivering thermogenesis (NST).  |  Robinson, S., et al. 2024. Comp Biochem Physiol A Mol Integr Physiol. 295: 111667. PMID: 38782254
9. Mutations in the gene-encoding SERCA1, the fast-twitch skeletal muscle sarcoplasmic reticulum Ca2+ ATPase, are associated with Brody disease.  |  Odermatt, A., et al. 1996. Nat Genet. 14: 191-4. PMID: 8841193
10. Fast- and slow-twitch isoforms (SERCA1 and SERCA2a) of sarcoplasmic reticulum Ca-ATPase are expressed simultaneously in chronically stimulated muscle fibers.  |  Zhang, KM., et al. 1997. Pflugers Arch. 433: 766-72. PMID: 9049168

The preferred SERCA1/2/3 antibody is SERCA1/2/3 Antibody (B-7): sc-271669.