SENP3 Antibody (E-7): sc-137219
- SENP3 Antibody (E-7) is a mouse monoclonal IgG1 κ SENP3 antibody provided at 200 µg/ml
- raised against amino acids 195-389 mapping within an internal region of SENP3 of human origin
- SENP3 Antibody (E-7) is recommended for detection of SENP3 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-SENP3 Antibody (E-7) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for SENP3 Antibody (E-7) for WB applications. These reagents are now offered in bundles with SENP3 Antibody (E-7) (see ordering information below).
SENP3 Antibody (E-7) is a mouse monoclonal IgG1 kappa light chain antibody that detects SENP3 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-SENP3 antibody (E-7) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. SENP3 plays a crucial role in the regulation of cellular processes by reversing the sumoylation of target proteins, which is essential for maintaining proper protein function and cellular homeostasis. Specifically, SENP3 enhances the transcriptional and myogenic activities of MEF2, a key transcription factor involved in muscle differentiation and development. By modulating the sumoylation status of MEF2, SENP3 influences gene expression patterns that are vital for muscle cell function and regeneration. Additionally, SENP3 activity is part of a larger network of sentrin-specific proteases that collectively regulate the dynamics of SUMO (small ubiquitin-related modifier) modifications, impacting various cellular functions such as transcription, DNA repair, and cell cycle progression. Understanding SENP3′s role in these processes is important for elucidating potential implications in muscle-related diseases and other conditions where SUMOylation is disrupted.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
SENP3 Antibody (E-7) References:
- Differential regulation of sentrinized proteins by a novel sentrin-specific protease. | Gong, L., et al. 2000. J Biol Chem. 275: 3355-9. PMID: 10652325
- A new SUMO-1-specific protease, SUSP1, that is highly expressed in reproductive organs. | Kim, KI., et al. 2000. J Biol Chem. 275: 14102-6. PMID: 10799485
- SENP1 enhances androgen receptor-dependent transcription through desumoylation of histone deacetylase 1. | Cheng, J., et al. 2004. Mol Cell Biol. 24: 6021-8. PMID: 15199155
- A basis for SUMO protease specificity provided by analysis of human Senp2 and a Senp2-SUMO complex. | Reverter, D. and Lima, CD. 2004. Structure. 12: 1519-31. PMID: 15296745
- Mapping residues of SUMO precursors essential in differential maturation by SUMO-specific protease, SENP1. | Xu, Z. and Au, SW. 2005. Biochem J. 386: 325-30. PMID: 15487983
- Desumoylation of homeodomain-interacting protein kinase 2 (HIPK2) through the cytoplasmic-nuclear shuttling of the SUMO-specific protease SENP1. | Kim, YH., et al. 2005. FEBS Lett. 579: 6272-8. PMID: 16253240
- The structure of SENP1-SUMO-2 complex suggests a structural basis for discrimination between SUMO paralogues during processing. | Shen, LN., et al. 2006. Biochem J. 397: 279-88. PMID: 16553580
- Characterization of a family of nucleolar SUMO-specific proteases with preference for SUMO-2 or SUMO-3. | Gong, L. and Yeh, ET. 2006. J Biol Chem. 281: 15869-77. PMID: 16608850
- The SUMO-specific protease SENP5 is required for cell division. | Di Bacco, A., et al. 2006. Mol Cell Biol. 26: 4489-98. PMID: 16738315
- SENP3 maintains the stability and function of regulatory T cells via BACH2 deSUMOylation. | Yu, X., et al. 2018. Nat Commun. 9: 3157. PMID: 30089837
- Iron chelation promotes mitophagy through SENP3-mediated deSUMOylation of FIS1. | Wilkinson, KA. and Guo, C. 2022. Autophagy. 18: 1743-1745. PMID: 35275026
- Suppression of SENP3 enhances macrophage alternative activation by mediating IRF4 de-SUMOylation in ESCC progression. | Zhang, S., et al. 2024. Cell Commun Signal. 22: 395. PMID: 39123188
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SENP3 Antibody (E-7) | sc-137219 | 200 µg/ml | $322.00 | |||
SENP3 Antibody (E-7): m-IgG Fc BP-HRP Bundle | sc-528877 | 200 µg Ab; 10 µg BP | $361.00 | |||
SENP3 Antibody (E-7): m-IgGκ BP-HRP Bundle | sc-521455 | 200 µg Ab, 40 µg BP | $361.00 | |||
SENP3 Antibody (E-7): m-IgG1 BP-HRP Bundle | sc-543186 | 200 µg Ab; 20 µg BP | $361.00 | |||
SENP3 Antibody (E-7) AC | sc-137219 AC | 500 µg/ml, 25% agarose | $424.00 | |||
SENP3 Antibody (E-7) HRP | sc-137219 HRP | 200 µg/ml | $322.00 | |||
SENP3 Antibody (E-7) FITC | sc-137219 FITC | 200 µg/ml | $336.00 | |||
SENP3 Antibody (E-7) PE | sc-137219 PE | 200 µg/ml | $349.00 | |||
SENP3 Antibody (E-7) Alexa Fluor® 488 | sc-137219 AF488 | 200 µg/ml | $364.00 | |||
SENP3 Antibody (E-7) Alexa Fluor® 546 | sc-137219 AF546 | 200 µg/ml | $364.00 | |||
SENP3 Antibody (E-7) Alexa Fluor® 594 | sc-137219 AF594 | 200 µg/ml | $364.00 | |||
SENP3 Antibody (E-7) Alexa Fluor® 647 | sc-137219 AF647 | 200 µg/ml | $364.00 | |||
SENP3 Antibody (E-7) Alexa Fluor® 680 | sc-137219 AF680 | 200 µg/ml | $364.00 | |||
SENP3 Antibody (E-7) Alexa Fluor® 790 | sc-137219 AF790 | 200 µg/ml | $364.00 |