secretin receptor Antibody (E-9): sc-166112
- secretin receptor Antibody (E-9) is a mouse monoclonal IgG1 κ secretin receptor antibody provided at 200 µg/ml
- raised against amino acids 33-121 mapping at the C-terminus of secretin of human origin
- secretin receptor Antibody (E-9) is recommended for detection of secretin precursor and active peptide of human origin by WB, IP, IF and ELISA
- Anti-secretin receptor Antibody (E-9) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for secretin receptor Antibody (E-9) for WB applications. These reagents are now offered in bundles with secretin receptor Antibody (E-9) (see ordering information below).
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SEE ALSO...
secretin receptor Antibody (E-9) is a mouse monoclonal IgG1 kappa light chain antibody that detects the secretin receptor protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). secretin receptor (E-9) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. The secretin receptor plays a crucial role in regulating digestive processes, particularly in stimulating bicarbonate-rich pancreatic juice secretion, which helps neutralize gastric acid in the duodenum. This receptor is mainly found on pancreatic ductal cells and cholangiocytes, where secretin receptor (E-9) monoclonal antibody mediates the effects of secretin, a 27-amino acid hormone produced by S cells in the proximal small intestine. The interaction between secretin and its receptor promotes bicarbonate secretion and enhances bile duct secretion, helping with digestion and nutrient absorption. The gene encoding the secretin receptor is located on human chromosome 11p15.5, and changes in its signaling pathway may be linked to various gastrointestinal disorders, highlighting its importance in digestive health and potential neuroendocrine functions.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
secretin receptor Antibody (E-9) References:
- Human secretin (SCT): gene structure, chromosome location, and distribution of mRNA. | Whitmore, TE., et al. 2000. Cytogenet Cell Genet. 90: 47-52. PMID: 11060443
- The mechanism of pancreatic secretion. | Bayliss, WM. and Starling, EH. 1902. J Physiol. 28: 325-53. PMID: 16992627
- Secretin: structure of the precursor and tissue distribution of the mRNA. | Kopin, AS., et al. 1990. Proc Natl Acad Sci U S A. 87: 2299-303. PMID: 2315322
- Structure of porcine secretin. The amino acid sequence. | Mutt, V., et al. 1970. Eur J Biochem. 15: 513-9. PMID: 5465996
- Secretin promotes osmotic water transport in rat cholangiocytes by increasing aquaporin-1 water channels in plasma membrane. Evidence for a secretin-induced vesicular translocation of aquaporin-1. | Marinelli, RA., et al. 1997. J Biol Chem. 272: 12984-8. PMID: 9148905
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
secretin receptor Antibody (E-9) | sc-166112 | 200 µg/ml | $316.00 | |||
secretin receptor Antibody (E-9): m-IgG Fc BP-HRP Bundle | sc-527138 | 200 µg Ab; 10 µg BP | $354.00 | |||
secretin receptor Antibody (E-9): m-IgG1 BP-HRP Bundle | sc-532511 | 200 µg Ab; 20 µg BP | $354.00 | |||
secretin receptor Antibody (E-9) AC | sc-166112 AC | 500 µg/ml, 25% agarose | $416.00 | |||
secretin receptor Antibody (E-9) HRP | sc-166112 HRP | 200 µg/ml | $316.00 | |||
secretin receptor Antibody (E-9) FITC | sc-166112 FITC | 200 µg/ml | $330.00 | |||
secretin receptor Antibody (E-9) PE | sc-166112 PE | 200 µg/ml | $343.00 | |||
secretin receptor Antibody (E-9) Alexa Fluor® 488 | sc-166112 AF488 | 200 µg/ml | $357.00 | |||
secretin receptor Antibody (E-9) Alexa Fluor® 546 | sc-166112 AF546 | 200 µg/ml | $357.00 | |||
secretin receptor Antibody (E-9) Alexa Fluor® 594 | sc-166112 AF594 | 200 µg/ml | $357.00 | |||
secretin receptor Antibody (E-9) Alexa Fluor® 647 | sc-166112 AF647 | 200 µg/ml | $357.00 | |||
secretin receptor Antibody (E-9) Alexa Fluor® 680 | sc-166112 AF680 | 200 µg/ml | $357.00 | |||
secretin receptor Antibody (E-9) Alexa Fluor® 790 | sc-166112 AF790 | 200 µg/ml | $357.00 |