Sec31A Antibody (H-2): sc-376587

Sec31A Antibody (H-2) is a mouse monoclonal IgG2a kappa light chain antibody that detects Sec31A of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-Sec31A antibody (H-2) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Sec31A, also known as ABP125, ABP130, or SEC31L1, is a 1,220 amino acid protein characterized by seven WD repeats, which are structural motifs that typically form a tertiary propeller configuration. These WD repeats are crucial for Sec31A′s role in the COP II (coat protein II) complex, where Sec31A is essential for forming transport vesicles from the endoplasmic reticulum and selecting cargo molecules for transport. Proper functioning of Sec31A maintains cellular homeostasis through vesicular trafficking, which is critical for transporting proteins and lipids within cells. Chromosomal aberrations involving Sec31A have been linked to inflammatory myofibroblastic tumors, indicating potential involvement in carcinogenesis. Multiple isoforms of Sec31A exist due to alternative splicing, highlighting regulatory potential in various cellular processes.

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Sec31A Antibody (H-2) References:

1. Mammalian homologues of yeast sec31p. An ubiquitously expressed form is localized to endoplasmic reticulum (ER) exit sites and is essential for ER-Golgi transport.  |  Tang, BL., et al. 2000. J Biol Chem. 275: 13597-604. PMID: 10788476
2. Secretory protein trafficking and organelle dynamics in living cells.  |  Lippincott-Schwartz, J., et al. 2000. Annu Rev Cell Dev Biol. 16: 557-89. PMID: 11031247
3. Three ways to make a vesicle.  |  Kirchhausen, T. 2000. Nat Rev Mol Cell Biol. 1: 187-98. PMID: 11252894
4. Fusion of the SEC31L1 and ALK genes in an inflammatory myofibroblastic tumor.  |  Panagopoulos, I., et al. 2006. Int J Cancer. 118: 1181-6. PMID: 16161041
5. Structure of the Sec13/31 COPII coat cage.  |  Stagg, SM., et al. 2006. Nature. 439: 234-8. PMID: 16407955
6. The Ca2+-binding protein ALG-2 is recruited to endoplasmic reticulum exit sites by Sec31A and stabilizes the localization of Sec31A.  |  Yamasaki, A., et al. 2006. Mol Biol Cell. 17: 4876-87. PMID: 16957052
7. Efficient coupling of Sec23-Sec24 to Sec13-Sec31 drives COPII-dependent collagen secretion and is essential for normal craniofacial development.  |  Townley, AK., et al. 2008. J Cell Sci. 121: 3025-34. PMID: 18713835

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Sec31A Antibody (H-2) has 9 citations in a variety of scientific publications.

Primary antibodies like Anti-Sec31A Antibody (H-2) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Sec31A Antibody (H-2) Specifications

Alternate Product Name: Sec31A

Product Clone Name: H-2

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 429-571

Epitope Target: Sec31A

Epitope Species: human

Product Reactivity/Detection: Sec31A

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 9 citations in various scientific publications

Available Conjugates/Forms for Sec31A Antibody (H-2): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin