SCML2 Antibody (E-12): sc-271096
- SCML2 Antibody (E-12) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- raised against amino acids 563-655 mapping near the C-terminus of SCML2 of human origin
- recommended for detection of SCML2 of mouse, rat and human origin by WB, IP, IF and ELISA
- m-IgGκ BP-HRP is the preferred secondary detection reagent for SCML2 Antibody (E-12) for WB applications. This reagent is now offered in a bundle with SCML2 Antibody (E-12) (see ordering information below). For additional m-IgGκ BP conjugates see our complete list of Mouse IgG Binding Proteins.
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SCML2 Antibody (E-12) is a mouse monoclonal IgG1 antibody that detects SCML2 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). SCML2, a human homolog of the Drosophila Polycomb protein SCM, plays a crucial role in transcriptional repression and is part of the Polycomb group (PcG) gene family, which is essential for regulating gene expression during embryonic development. SCML2 is predominantly expressed in the placenta, testis, and thymus, highlighting its importance in reproductive and immune functions. Notably, SCML2 undergoes post-translational modifications, including phosphorylation by ATR or ATM in response to DNA damage, which can influence activity and stability. Additionally, alternative splicing of SCML2 results in two isoforms, allowing for functional diversity that may be critical in various biological contexts. Anti-SCML2 antibody (E-12) effectively detects SCML2 across multiple species and applications, making SCML2 (E-12) antibody an invaluable tool for researchers studying gene regulation and developmental biology.
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SCML2 Antibody (E-12) References:
- Polycomb protein SCML2 regulates the cell cycle by binding and modulating CDK/CYCLIN/p21 complexes. | Lecona, E., et al. 2013. PLoS Biol. 11: e1001737. PMID: 24358021
- USP7 cooperates with SCML2 to regulate the activity of PRC1. | Lecona, E., et al. 2015. Mol Cell Biol. 35: 1157-68. PMID: 25605328
- SCML2 establishes the male germline epigenome through regulation of histone H2A ubiquitination. | Hasegawa, K., et al. 2015. Dev Cell. 32: 574-88. PMID: 25703348
- RNF8 and SCML2 cooperate to regulate ubiquitination and H3K27 acetylation for escape gene activation on the sex chromosomes. | Adams, SR., et al. 2018. PLoS Genet. 14: e1007233. PMID: 29462142
- Polycomb protein SCML2 facilitates H3K27me3 to establish bivalent domains in the male germline. | Maezawa, S., et al. 2018. Proc Natl Acad Sci U S A. 115: 4957-4962. PMID: 29686098
- SCML2 promotes heterochromatin organization in late spermatogenesis. | Maezawa, S., et al. 2018. J Cell Sci. 131: PMID: 30097555
- A rapidly evolved domain, the SCML2 DNA-binding repeats, contributes to chromatin binding of mouse SCML2†. | Maezawa, S., et al. 2019. Biol Reprod. 100: 409-419. PMID: 30137219
- Polycomb protein SCML2 mediates paternal epigenetic inheritance through sperm chromatin. | Sakashita, A., et al. 2023. Nucleic Acids Res. 51: 6668-6683. PMID: 37283086
- SCML2 contributes to tumor cell resistance to DNA damage through regulating p53 and CHK1 stability. | Peng, Q., et al. 2023. Cell Death Differ. 30: 1849-1867. PMID: 37353627
- Discordant interactions between YAP1 and polycomb group protein SCML2 determine cell fate. | Boston, AM., et al. 2023. iScience. 26: 107964. PMID: 37810219
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SCML2 Antibody (E-12) | sc-271096 | 200 µg/ml | $316.00 | |||
SCML2 Antibody (E-12): m-IgGκ BP-HRP Bundle | sc-521848 | 200 µg Ab, 40 µg BP | $354.00 |