SCML2 Antibody (C-12): sc-393243
- SCML2 Antibody (C-12) is a mouse monoclonal IgM κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 561-597 within an internal region of SCML2 of human origin
- recommended for detection of SCML2 isoforms 1 and 2 of mouse, rat, human origin by WB, IP, IF and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for SCML2 Antibody (C-12). This work is in progress.
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SCML2 Antibody (C-12) is a mouse monoclonal IgM antibody that detects SCML2 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). SCML2, a human homolog of the Drosophila Polycomb protein SCM, plays a crucial role in transcriptional repression and is essential for regulating gene expression during development. SCML2 is predominantly expressed in the placenta, testis, and thymus, highlighting SCML2′s importance in reproductive and immune functions. Notably, SCML2 undergoes post-translational modifications, including phosphorylation by ATR or ATM in response to DNA damage, which can influence SCML2′s activity and stability. Additionally, alternative splicing of SCML2 results in two isoforms, allowing for functional diversity that may be critical in various biological contexts. Anti-SCML2 antibody (C-12) is an invaluable tool for researchers studying gene regulation, developmental biology, and cellular responses to DNA damage.
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SCML2 Antibody (C-12) References:
- Identification of SCML2, a second human gene homologous to the Drosophila sex comb on midleg (Scm): A new gene cluster on Xp22. | Montini, E., et al. 1999. Genomics. 58: 65-72. PMID: 10331946
- Crystal structure of the malignant brain tumor (MBT) repeats in Sex Comb on Midleg-like 2 (SCML2). | Sathyamurthy, A., et al. 2003. J Biol Chem. 278: 46968-73. PMID: 12952983
- The malignant brain tumor repeats of human SCML2 bind to peptides containing monomethylated lysine. | Santiveri, CM., et al. 2008. J Mol Biol. 382: 1107-12. PMID: 18706910
- Polycomb protein SCML2 regulates the cell cycle by binding and modulating CDK/CYCLIN/p21 complexes. | Lecona, E., et al. 2013. PLoS Biol. 11: e1001737. PMID: 24358021
- Solution NMR structure of the DNA-binding domain from Scml2 (sex comb on midleg-like 2). | Bezsonova, I. 2014. J Biol Chem. 289: 15739-49. PMID: 24727478
- Interactions with RNA direct the Polycomb group protein SCML2 to chromatin where it represses target genes. | Bonasio, R., et al. 2014. Elife. 3: e02637. PMID: 24986859
- Mammalian SWI/SNF collaborates with a polycomb-associated protein to regulate male germline transcription in the mouse. | Menon, DU., et al. 2019. Development. 146: PMID: 31043422
- Sex Comb on Midleg Like-2 Accelerates Hepatocellular Carcinoma Cell Proliferation and Metastasis by Activating Wnt/β-Catenin/EMT Signaling. | Du, L., et al. 2021. Yonsei Med J. 62: 1073-1082. PMID: 34816637
- CTCF-mediated 3D chromatin predetermines the gene expression program in the male germline. | Kitamura, Y., et al. 2023. bioRxiv.. PMID: 38076840
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SCML2 Antibody (C-12) | sc-393243 | 200 µg/ml | $322.00 | |||
SCML2 (C-12) Neutralizing Peptide | sc-393243 P | 100 µg/0.5 ml | $69.00 |