Sar1a Antibody (K-44): sc-130463

Sar1a Antibody (K-44) is a mouse monoclonal IgG2b kappa light chain antibody that detects Sar1a protein of mouse, rat, and human origin by western blotting (WB) and immunoprecipitation (IP). Anti-Sar1a antibody (K-44) is available as a non-conjugated format, providing researchers with a reliable tool for studying this critical protein. Sar1a plays a vital role in the secretory pathway of cells, specifically in the formation of transport vesicles from the endoplasmic reticulum (ER). Sar1a functions as a low-molecular-weight GTPase essential for the budding of COPII-coated vesicles, which are responsible for transporting secretory proteins to the Golgi complex. Understanding Sar1a function is crucial, as mutations in the SAR1 gene can lead to Anderson′s disease, a rare autosomal recessive disorder characterized by severe lipid malabsorption, chronic diarrhea, and failure to thrive in children. Sar1a (K-44) antibody enables researchers to gain insights into the mechanisms of vesicular transport and the implications of SAR1 gene mutations in various diseases, making this tool invaluable in cellular biology and disease research.

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Sar1a Antibody (K-44) References:

1. The intracellular transport of chylomicrons requires the small GTPase, Sar1b.  |  Shoulders, CC., et al. 2004. Curr Opin Lipidol. 15: 191-7. PMID: 15017362
2. Sequence identification, tissue distribution, mapping and polymorphism of the porcine sar1b gene.  |  Wang, XM., et al. 2006. Anim Biotechnol. 17: 99-107. PMID: 16621763
3. Anderson or chylomicron retention disease: molecular impact of five mutations in the SAR1B gene on the structure and the functionality of Sar1b protein.  |  Charcosset, M., et al. 2008. Mol Genet Metab. 93: 74-84. PMID: 17945526
4. Anderson's disease (chylomicron retention disease): a new mutation in the SARA2 gene associated with muscular and cardiac abnormalities.  |  Silvain, M., et al. 2008. Clin Genet. 74: 546-52. PMID: 18786134
5. Circ-SAR1A Promotes Renal Cell Carcinoma Progression Through miR-382/YBX1 Axis.  |  Zhao, X., et al. 2020. Cancer Manag Res. 12: 7353-7361. PMID: 32884349
6. Circ_SAR1A regulates the malignant behavior of lung cancer cells via the miR-21-5p/TXNIP axis.  |  Zhao, Y., et al. 2022. J Clin Lab Anal. 36: e24366. PMID: 35334496
7. SAR1A regulates the RhoA/YAP and autophagy signaling pathways to influence osteosarcoma invasion and metastasis.  |  Zhan, F., et al. 2022. Cancer Sci. 113: 4104-4119. PMID: 36047971
8. Sar1 promotes vesicle budding from the endoplasmic reticulum but not Golgi compartments.  |  Kuge, O., et al. 1994. J Cell Biol. 125: 51-65. PMID: 8138575
9. Transcriptional studies on yeast SEC genes provide no evidence for regulation at the transcriptional level.  |  Vahlensieck, Y., et al. 1995. Yeast. 11: 901-11. PMID: 8533466
10. Sec31 encodes an essential component of the COPII coat required for transport vesicle budding from the endoplasmic reticulum.  |  Salama, NR., et al. 1997. Mol Biol Cell. 8: 205-17. PMID: 9190202
11. Protein and lipid sorting between the endoplasmic reticulum and the Golgi complex.  |  Nickel, W., et al. 1998. Semin Cell Dev Biol. 9: 493-501. PMID: 9835636
12. Identification of SEC12, SED4, truncated SEC16, and EKS1/HRD3 as multicopy suppressors of ts mutants of Sar1 GTPase.  |  Saito, Y., et al. 1999. J Biochem. 125: 130-7. PMID: 9880808

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Sar1a Antibody (K-44) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-Sar1a Antibody (K-44) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Sar1a Antibody (K-44) Specifications

Alternate Product Name: Sar1a

Product Clone Name: K-44

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 1-199

Epitope Target: Sar1a

Epitope Species: human

Product Reactivity/Detection: Sar1a

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP

Vialing Information: Each vial contains 100 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for Sar1a Antibody (K-44): N/A