SAPK4 Antibody (GST-D1): sc-33691
- SAPK4 Antibody (GST-D1) is a mouse monoclonal IgG2a κ provided at 200 µg/ml
- raised against recombinant p38 of human origin
- recommended for detection of SAPK4 (p38δ) of human origin by WB and IP; may cross-react with p38α, p38β and p38γ
- m-IgG Fc BP-HRP, m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for SAPK4 Antibody (GST-D1) for WB applications. These reagents are now offered in bundles with SAPK4 Antibody (GST-D1) (see ordering information below).
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SEE ALSO...
SAPK4 Antibody (GST-D1) is a mouse monoclonal IgG2a antibody that detects SAPK4 in human samples through western blotting (WB) and immunoprecipitation (IP) applications. SAPK4, also known as stress-activated protein kinase-4, plays a crucial role in cellular responses to stress and inflammation, making SAPK4 an important target for research in various diseases, including cancer and neurodegenerative disorders. SAPK4 is primarily located in the cytoplasm, where SAPK4 is activated by upstream kinases in response to cytokines and environmental stressors. The cytoplasmic localization of SAPK4 allows for rapid signaling cascades that can influence cell survival, apoptosis, and differentiation. SAPK4 interacts with several key proteins, including MKK6, which phosphorylates SAPK4, thereby activating kinase activity. Understanding SAPK4 dynamics and interactions is essential for elucidating SAPK4′s role in cellular signaling pathways and developing potential therapeutic strategies targeting stress-related diseases.
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SAPK4 Antibody (GST-D1) References:
- Regulation of sodium iodide symporter gene expression by Rac1/p38β mitogen-activated protein kinase signaling pathway in MCF-7 breast cancer cells. | Kogai, T., et al. 2012. J Biol Chem. 287: 3292-300. PMID: 22157753
- MAPK11 in breast cancer cells enhances osteoclastogenesis and bone resorption. | He, Z., et al. 2014. Biochimie. 106: 24-32. PMID: 25066918
- Suppression of MAPK11 or HIPK3 reduces mutant Huntingtin levels in Huntington's disease models. | Yu, M., et al. 2017. Cell Res. 27: 1441-1465. PMID: 29151587
- Circ_0001955 facilitates hepatocellular carcinoma (HCC) tumorigenesis by sponging miR-516a-5p to release TRAF6 and MAPK11. | Yao, Z., et al. 2019. Cell Death Dis. 10: 945. PMID: 31822654
- p38β (MAPK11) mediates gemcitabine-associated radiosensitivity in sarcoma experimental models. | Pascual-Serra, R., et al. 2021. Radiother Oncol. 156: 136-144. PMID: 33310004
- p38β - MAPK11 and its role in female cancers. | Katopodis, P., et al. 2021. J Ovarian Res. 14: 84. PMID: 34174910
- Design, Synthesis, and Structure-Activity Relationship Study of Potent MAPK11 Inhibitors. | Gong, M., et al. 2021. Molecules. 27: PMID: 35011435
- miR-143-Mediated Responses to Betaine Supplement Repress Lipogenesis and Hepatic Gluconeogenesis by Targeting MAT1a and MAPK11. | Chen, X., et al. 2022. J Agric Food Chem. 70: 7981-7992. PMID: 35734958
- SARS-CoV-2 hijacks p38β/MAPK11 to promote virus replication. | Higgins, CA., et al. 2023. mBio. 14: e0100723. PMID: 37345956
- Activation of the novel stress-activated protein kinase SAPK4 by cytokines and cellular stresses is mediated by SKK3 (MKK6); comparison of its substrate specificity with that of other SAP kinases. | Goedert, M., et al. 1997. EMBO J. 16: 3563-71. PMID: 9218798
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SAPK4 Antibody (GST-D1) | sc-33691 | 200 µg/ml | $322.00 | |||
SAPK4 Antibody (GST-D1): m-IgG Fc BP-HRP Bundle | sc-536779 | 200 µg Ab; 10 µg BP | $361.00 | |||
SAPK4 Antibody (GST-D1): m-IgGκ BP-HRP Bundle | sc-533943 | 200 µg Ab; 40 µg BP | $361.00 | |||
SAPK4 Antibody (GST-D1): m-IgG2a BP-HRP Bundle | sc-547868 | 200 µg Ab; 10 µg BP | $361.00 |