SAPK4 Antibody (E-7): sc-46678

SAPK4 Antibody (E-7) is a mouse monoclonal IgG1 kappa light chain antibody that detects SAPK4 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-SAPK4 antibody (E-7) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. SAPK4 protein, also known as stress-activated protein kinase-4 or p38d, plays a crucial role in cellular responses to stress and inflammation, being phosphorylated by MKK6 in response to cytokines and various cellular stresses. This phosphorylation is vital for the activation of downstream signaling pathways that regulate gene expression, cell differentiation, and apoptosis, highlighting SAPK4′s importance in maintaining cellular homeostasis and responding to environmental challenges. SAPK4 shares structural similarities with other members of the MAP kinase family, such as p38 and Hog1, which allows participation in similar signaling cascades, further emphasizing SAPK4′s significance in cellular stress responses.

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SAPK4 Antibody (E-7) References:

1. p38α and p38β mitogen-activated protein kinases determine cholinergic transdifferentiation of sympathetic neurons.  |  Loy, B., et al. 2011. J Neurosci. 31: 12059-67. PMID: 21865449
2. The p38β mitogen-activated protein kinase possesses an intrinsic autophosphorylation activity, generated by a short region composed of the α-G helix and MAPK insert.  |  Beenstock, J., et al. 2014. J Biol Chem. 289: 23546-56. PMID: 25006254
3. The problem of pyridinyl imidazole class inhibitors of MAPK14/p38α and MAPK11/p38β in autophagy research.  |  Menon, MB., et al. 2015. Autophagy. 11: 1425-7. PMID: 26061537
4. Roles of p38α and p38β mitogen‑activated protein kinase isoforms in human malignant melanoma A375 cells.  |  Wen, SY., et al. 2019. Int J Mol Med. 44: 2123-2132. PMID: 31661126
5. An osmosensing signal transduction pathway in yeast.  |  Brewster, JL., et al. 1993. Science. 259: 1760-3. PMID: 7681220
6. Endotoxin induces rapid protein tyrosine phosphorylation in 70Z/3 cells expressing CD14.  |  Han, J., et al. 1993. J Biol Chem. 268: 25009-14. PMID: 7693711
7. A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells.  |  Han, J., et al. 1994. Science. 265: 808-11. PMID: 7914033
8. The MAP kinase cascade is essential for diverse signal transduction pathways.  |  Nishida, E. and Gotoh, Y. 1993. Trends Biochem Sci. 18: 128-31. PMID: 8388132
9. Characterization of the structure and function of a new mitogen-activated protein kinase (p38beta).  |  Jiang, Y., et al. 1996. J Biol Chem. 271: 17920-6. PMID: 8663524
10. Novel homologues of CSBP/p38 MAP kinase: activation, substrate specificity and sensitivity to inhibition by pyridinyl imidazoles.  |  Kumar, S., et al. 1997. Biochem Biophys Res Commun. 235: 533-8. PMID: 9207191
11. Activation of the novel stress-activated protein kinase SAPK4 by cytokines and cellular stresses is mediated by SKK3 (MKK6); comparison of its substrate specificity with that of other SAP kinases.  |  Goedert, M., et al. 1997. EMBO J. 16: 3563-71. PMID: 9218798
12. Molecular cloning and characterization of a novel p38 mitogen-activated protein kinase.  |  Wang, XS., et al. 1997. J Biol Chem. 272: 23668-74. PMID: 9295308

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-SAPK4 Antibody (E-7) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-SAPK4 Antibody (E-7) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

SAPK4 Antibody (E-7) Specifications

Alternate Product Name: SAPK4

Product Clone Name: E-7

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 306-365

Epitope Target: SAPK4

Epitope Species: human

Product Reactivity/Detection: SAPK4

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for SAPK4 Antibody (E-7): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, PE: Phycoerythrin