SAPK4 Inhibitors
SAPK4, also known as stress-activated protein kinase 4 or c-Jun N-terminal kinase 3 (JNK3), belongs to the family of mitogen-activated protein kinases (MAPKs) and plays a crucial role in cellular stress response pathways. Its function is intricately tied to the regulation of various cellular processes, including cell proliferation, differentiation, apoptosis, and inflammation. Specifically, SAPK4 is involved in signaling cascades triggered by environmental stresses such as UV radiation, heat shock, and inflammatory cytokines. Upon activation, SAPK4 phosphorylates a variety of downstream targets, including transcription factors such as c-Jun, ATF2, and p53, which subsequently regulate gene expression to elicit appropriate cellular responses.
Inhibition of SAPK4 is a significant area of interest due to its implication in various pathological conditions, including neurodegenerative diseases, cancer, and inflammatory disorders. Mechanistically, inhibition of SAPK4 can be achieved through targeting different stages of its signaling pathway. One approach involves blocking the upstream kinases responsible for SAPK4 activation, such as MKK4 and MKK7. Additionally, small molecule inhibitors can directly target the catalytic domain of SAPK4, preventing its phosphorylation activity. Moreover, modulating the activity of scaffolding proteins that facilitate SAPK4 activation and signaling can also serve as a strategy for inhibition. By interfering with SAPK4-mediated signaling, inhibitors may attenuate the detrimental effects associated with aberrant SAPK4 activity, offering benefits in diseases where SAPK4 dysregulation is implicated.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is a potent activator of protein kinase C (PKC), a signaling molecule involved in diverse cellular processes. Flightless I interacts with various signaling pathways, and PMA, through PKC activation, potentially modulates Flightless I-mediated cellular processes related to cytoskeletal dynamics, cell motility, and migration. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $56.00 $156.00 $270.00 $665.00 | 37 | |
PGE2 is a lipid mediator with various cellular effects, including modulation of intracellular signaling. Flightless I is associated with signaling pathways influenced by PGE2, and this molecule can potentially activate Flightless I by influencing downstream pathways involved in cytoskeletal dynamics, cell motility, and migration. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
TSA is a histone deacetylase (HDAC) inhibitor, affecting gene expression. Flightless I expression may be influenced by chromatin modifications, and TSA, by inhibiting HDACs, can potentially activate Flightless I expression, impacting cellular processes related to cytoskeletal dynamics and motility. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor, impacting the PI3K/Akt signaling pathway. Flightless I is linked to PI3K signaling, and LY294002, by inhibiting PI3K, may potentially activate Flightless I by modulating downstream signaling pathways involved in cytoskeletal dynamics, cell motility, and migration. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylyl cyclase, leading to increased cAMP levels. Flightless I is associated with cAMP signaling pathways, and Forskolin, by elevating cAMP, can potentially activate Flightless I-mediated cellular processes related to cytoskeletal dynamics, cell motility, and migration. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187 is a calcium ionophore, influencing intracellular calcium levels. Flightless I is implicated in calcium-dependent signaling, and A23187, by modulating calcium levels, may potentially activate Flightless I-mediated cellular processes related to cytoskeletal dynamics, cell motility, and migration. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic Acid is a derivative of vitamin A that regulates gene expression. Flightless I expression may be influenced by retinoic acid, and this molecule can potentially activate Flightless I by impacting gene transcription, thereby modulating cellular processes related to cytoskeletal dynamics and motility. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $45.00 $130.00 $480.00 $4450.00 | 74 | |
Dibutyryl-cAMP is a cell-permeable analog of cAMP. Flightless I is linked to cAMP signaling pathways, and Dibutyryl-cAMP, by mimicking the effects of cAMP, can potentially activate Flightless I-mediated cellular processes related to cytoskeletal dynamics, cell motility, and migration. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore, influencing intracellular calcium levels. Flightless I is implicated in calcium-dependent signaling, and Ionomycin, by modulating calcium levels, may potentially activate Flightless I-mediated cellular processes related to cytoskeletal dynamics, cell motility, and migration. | ||||||