SAP 49 Antibody (G-7): sc-398944

SAP 49 Antibody (G-7) is a mouse monoclonal IgG2a antibody that detects SAP 49 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). SAP 49 is a crucial component of the U2 small nuclear ribonucleoprotein (snRNP) complex, which is essential for the assembly of the spliceosome, a vital molecular machine responsible for the splicing of pre-mRNA. SAP 49′s primary function involves interaction with other spliceosomal proteins, including SAP 145, which is critical for the proper recognition and binding of the U2 snRNP to the branch site of pre-mRNA. This interaction is facilitated by the amino-terminus of SAP 49, which contains two RNA-recognition motifs essential for binding capabilities. SAP 49′s direct interaction with both U2 snRNP and pre-mRNA underscores a significant role in the splicing process, making SAP 49 a key player in gene expression regulation. Anti-SAP 49 antibody (G-7) is an invaluable tool for researchers studying the dynamics of spliceosome assembly and the intricate mechanisms of mRNA processing.

The preferred SAP 49 antibody is SAP 49 Antibody (G-12): sc-365570.