Sam 68 Antibody (C-7): sc-514404
- Sam 68 Antibody (C-7) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- raised against amino acids 331-443 of Sam 68 of mouse origin
- recommended for detection of Sam 68 of mouse and rat origin by WB, IP, IF and ELISA
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Sam 68 Antibody (C-7) for WB applications. These reagents are now offered in bundles with Sam 68 Antibody (C-7) (see ordering information below).
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Sam 68 Antibody (C-7) is a mouse monoclonal IgG1 antibody that detects Sam 68 in mouse and rat samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Sam 68 (C-7) antibody recognizes a multifunctional protein that plays a crucial role in cellular signaling and RNA metabolism, primarily functioning as an RNA-binding protein that influences mRNA splicing and stability. Sam 68 (C-7) monoclonal antibody targets a protein known to interact with various signaling molecules, including GRB2 and PLC γ1, highlighting Sam 68′s importance in mediating signal transduction pathways, particularly during mitosis when precise regulation of gene expression is vital for cell division and function. Sam 68 undergoes post-translational modifications, such as tyrosine phosphorylation, which can modulate Sam 68′s activity and interactions with other proteins, further emphasizing Sam 68′s role as a key player in cellular signaling networks. anti-Sam 68 antibody (C-7) serves as an essential tool for researchers investigating the dynamics of RNA-binding proteins and their implications in cellular processes and diseases.
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Sam 68 Antibody (C-7) References:
- Regulation of gene expression by the RNA-binding protein Sam68 in cancer. | Rajan, P., et al. 2008. Biochem Soc Trans. 36: 505-7. PMID: 18481990
- Expression and functions of the star proteins Sam68 and T-STAR in mammalian spermatogenesis. | Ehrmann, I. and Elliott, DJ. 2010. Adv Exp Med Biol. 693: 67-81. PMID: 21189686
- Mechanisms of HGF/Met signaling to Brk and Sam68 in breast cancer progression. | Locatelli, A., et al. 2012. Horm Cancer. 3: 14-25. PMID: 22124844
- Emerging roles for Sam68 in adipogenesis and neuronal development. | Vogel, G. and Richard, S. 2012. RNA Biol. 9: 1129-33. PMID: 23018781
- Role of Sam68 in post-transcriptional gene regulation. | Sánchez-Jiménez, F. and Sánchez-Margalet, V. 2013. Int J Mol Sci. 14: 23402-19. PMID: 24287914
- Sam68 functions as a transcriptional coactivator of the p53 tumor suppressor. | Li, N. and Richard, S. 2016. Nucleic Acids Res. 44: 8726-8741. PMID: 27365047
- Sam68 is a regulator of Toll-like receptor signaling. | Tomalka, JA., et al. 2017. Cell Mol Immunol. 14: 107-117. PMID: 27374795
- Sam68 impedes the recovery of arterial injury by augmenting inflammatory response. | Han, S., et al. 2019. J Mol Cell Cardiol. 137: 82-92. PMID: 31639388
- Sam68 promotes aerobic glycolysis in colorectal cancer by regulating PKM2 alternative splicing. | Zhao, J., et al. 2020. Ann Transl Med. 8: 459. PMID: 32395503
- ITSN1 regulates SAM68 solubility through SH3 domain interactions with SAM68 proline-rich motifs. | Pankivskyi, S., et al. 2021. Cell Mol Life Sci. 78: 1745-1763. PMID: 32780150
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Sam 68 Antibody (C-7) | sc-514404 | 200 µg/ml | $316.00 | |||
Sam 68 Antibody (C-7): m-IgG Fc BP-HRP Bundle | sc-538638 | 200 µg Ab; 10 µg BP | $354.00 | |||
Sam 68 Antibody (C-7): m-IgGκ BP-HRP Bundle | sc-536286 | 200 µg Ab; 40 µg BP | $354.00 | |||
Sam 68 Antibody (C-7): m-IgG1 BP-HRP Bundle | sc-545804 | 200 µg Ab; 20 µg BP | $354.00 |