Sab Antibody (PL-A23): sc-135617

Sab Antibody (PL-A23) is a mouse monoclonal IgG1 antibody that detects Sab in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Sab is a Src homology 3 domain (SH3) binding protein that plays a critical role in regulating Bruton′s tyrosine kinase (Btk), a key player in B cell development. Anti-Sab antibody (PL-A23) recognizes the interaction between Sab and Btk, which serves as a negative regulatory mechanism; Sab binding to Btk inhibits kinase activity, thereby reducing phosphorylation of Btk substrates and preventing Btk-induced auto-phosphorylation in B cells. This regulatory function is vital, as Btk is essential for proper B cell maturation, and Btk deficiency can lead to severe immunodeficiencies such as X-linked agammaglobulinemia in humans. While Btk is primarily expressed in B cells, Sab shows broader distribution across various tissues, suggesting potential interactions with other protein kinases and influence on diverse signaling pathways. Sab monoclonal antibody (PL-A23) serves as an invaluable tool for researchers studying B cell signaling and regulatory networks governing immune responses.

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Sab Antibody (PL-A23) References:

1. Staphylococcus aureus bacteremia.  |  Jensen, AG. 2003. Dan Med Bull. 50: 423-38. PMID: 14694855
2. Sab, a novel autotransporter of locus of enterocyte effacement-negative shiga-toxigenic Escherichia coli O113:H21, contributes to adherence and biofilm formation.  |  Herold, S., et al. 2009. Infect Immun. 77: 3234-43. PMID: 19487483
3. C1q-fixing human leukocyte antigen assay in immunized renal patients: correlation between Luminex SAB-C1q and SAB-IgG.  |  Llorente, S., et al. 2012. Transplant Proc. 44: 2535-7. PMID: 23146446
4. Staphylococcus aureus bacteraemia and endocarditis - epidemiology and outcome: a review.  |  Asgeirsson, H., et al. 2018. Infect Dis (Lond). 50: 175-192. PMID: 29105519
5. The clinical significance of concomitant bacteriuria in patients with Staphylococcus aureus bacteremia. A review and meta-analysis.  |  Karakonstantis, S. and Kalemaki, D. 2018. Infect Dis (Lond). 50: 648-659. PMID: 29489435
6. Incidence Trends and Epidemiology of Staphylococcus aureus Bacteremia: A Systematic Review of Population-Based Studies.  |  Hindy, JR., et al. 2022. Cureus. 14: e25460. PMID: 35774691
7. Possible applications of salvianolic acid B against different cancers.  |  Shahzadi, I., et al. 2020. Explor Target Antitumor Ther. 1: 218-238. PMID: 36046777
8. Relationship between platelet activation markers and spontaneous abortion: A meta-analysis.  |  Gao, H., et al. 2022. Open Life Sci. 17: 1669-1678. PMID: 36567721
9. Sequential oral antibiotic in uncomplicated Staphylococcus aureus bacteraemia: a propensity-matched cohort analysis.  |  Diego-Yagüe, I., et al. 2023. Clin Microbiol Infect. 29: 744-750. PMID: 36773773
10. Risk Factors and Outcomes of Hematogenous Vertebral Osteomyelitis in Patients With Staphylococcus aureus Bacteremia.  |  Kinamon, T., et al. 2023. Clin Infect Dis. 77: 1226-1233. PMID: 37747828
11. Clinical Subphenotypes of Staphylococcus aureus Bacteremia.  |  Swets, MC., et al. 2024. Clin Infect Dis. 79: 1153-1161. PMID: 38916975
12. Identification and characterization of a novel SH3-domain binding protein, Sab, which preferentially associates with Bruton's tyrosine kinase (BtK).  |  Matsushita, M., et al. 1998. Biochem Biophys Res Commun. 245: 337-43. PMID: 9571151

The preferred Sab antibody is Sab Antibody (A-3): sc-390512.