RXRγ Antibody (A-2): sc-365252

RXRγ Antibody (A-2) is a mouse monoclonal IgG2b kappa light chain antibody that detects RXRγ protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-RXRγ antibody (A-2) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates, providing versatility for different experimental needs. RXRγ protein plays a crucial role in mediating the effects of retinoic acid, a vital signaling molecule involved in numerous biological processes, including cell differentiation, growth, and apoptosis. RXRγ is primarily located in the nucleus, where RXRγ functions as a transcription factor that regulates gene expression in response to retinoic acid and other ligands. RXRγ′s ability to form heterodimers with other nuclear receptors, such as retinoic acid receptors and thyroid hormone receptors, enhances regulatory capacity, making RXRγ essential for maintaining cellular homeostasis and responding to hormonal signals. Understanding RXRγ function and interactions is important for elucidating RXRγ′s role in various physiological and pathological processes, including development and cancer.

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RXRγ Antibody (A-2) References:

1. 9-cis retinoic acid stereoisomer binds and activates the nuclear receptor RXR alpha.  |  Levin, AA., et al. 1992. Nature. 355: 359-61. PMID: 1309942
2. 9-cis retinoic acid is a high affinity ligand for the retinoid X receptor.  |  Heyman, RA., et al. 1992. Cell. 68: 397-406. PMID: 1310260
3. Mapping of the mouse Rxr loci encoding nuclear retinoid X receptors RXR alpha, RXR beta, and RXR gamma.  |  Hoopes, CW., et al. 1992. Genomics. 14: 611-7. PMID: 1358808
4. Characterization of DNA binding and retinoic acid binding properties of retinoic acid receptor.  |  Yang, N., et al. 1991. Proc Natl Acad Sci U S A. 88: 3559-63. PMID: 1850832
5. The Drosophila EcR gene encodes an ecdysone receptor, a new member of the steroid receptor superfamily.  |  Koelle, MR., et al. 1991. Cell. 67: 59-77. PMID: 1913820
6. A functional retinoic acid receptor encoded by the gene on human chromosome 12.  |  Ishikawa, T., et al. 1990. Mol Endocrinol. 4: 837-44. PMID: 2172793
7. Expression proteomics predicts loss of RXR-γ during progression of epithelial ovarian cancer.  |  Kalra, RS. and Bapat, SA. 2013. PLoS One. 8: e70398. PMID: 23936423
8. Proteomics to Predict Loss of RXR-γ During Progression of Epithelial Ovarian Cancer.  |  Kalra, RS. and Bapat, SA. 2019. Methods Mol Biol. 2019: 1-14. PMID: 31359385
9. The Cytoskeletal Protein Zyxin Inhibits Retinoic Acid Signaling by Destabilizing the Maternal mRNA of the RXRγ Nuclear Receptor.  |  Parshina, EA., et al. 2022. Int J Mol Sci. 23: PMID: 35628438
10. Rational Design of a New RXR Agonist Scaffold Enabling Single-Subtype Preference for RXRα, RXRβ, and RXRγ.  |  Adouvi, G., et al. 2023. J Med Chem. 66: 333-344. PMID: 36533416
11. Phosphorylation enhances the target gene sequence-dependent dimerization of thyroid hormone receptor with retinoid X receptor.  |  Bhat, MK., et al. 1994. Proc Natl Acad Sci U S A. 91: 7927-31. PMID: 8058736
12. RXR gamma null mice are apparently normal and compound RXR alpha +/-/RXR beta -/-/RXR gamma -/- mutant mice are viable.  |  Krezel, W., et al. 1996. Proc Natl Acad Sci U S A. 93: 9010-4. PMID: 8799145

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-RXRγ Antibody (A-2) has 18 citations in a variety of scientific publications.

Primary antibodies like Anti-RXRγ Antibody (A-2) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

RXRγ Antibody (A-2) Specifications

Alternate Product Name: Retinoid X receptor gamma

Product Clone Name: A-2

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 1-105

Epitope Target: RXRγ

Epitope Species: human

Product Reactivity/Detection: RXRγ

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 18 citations in various scientific publications

Available Conjugates/Forms for RXRγ Antibody (A-2): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin, X: TransCruz Reagent

The preferred RXRα/β/γ antibody is RXRα/β/γ Antibody (F-1): sc-46659.