RXRβ Antibody (13-17): sc-741

RXRβ Antibody (13-17) is a mouse monoclonal IgG1 antibody that detects RXRβ in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). RXRβ, a member of the retinoid X receptor family, plays a crucial role in mediating the effects of retinoic acid, which is vital for various biological processes including cell differentiation, growth, and embryonic development. RXRβ is primarily located in the nucleus, where RXRβ functions as a transcription factor that regulates gene expression in response to retinoid signaling. Nuclear localization of RXRβ enables interaction with specific DNA sequences and formation of heterodimers with other nuclear receptors, such as retinoic acid receptors (RARs), thereby enhancing or repressing the transcription of target genes. Formation of these complexes is critical for proper regulation of genes involved in metabolic processes and developmental pathways, highlighting RXRβ′s importance in maintaining cellular homeostasis and responding to hormonal signals. Anti-RXRβ antibody (13-17) serves as an invaluable tool for researchers studying the intricate mechanisms of retinoid signaling and its implications in health and disease.

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RXRβ Antibody (13-17) References:

1. Photoaffinity labeling of human retinoid X receptor beta (RXRbeta) with 9-cis-retinoic acid: identification of phytanic acid, docosahexaenoic acid, and lithocholic acid as ligands for RXRbeta.  |  Radominska-Pandya, A. and Chen, G. 2002. Biochemistry. 41: 4883-90. PMID: 11939783
2. Crystal structure of the heterodimeric complex of LXRalpha and RXRbeta ligand-binding domains in a fully agonistic conformation.  |  Svensson, S., et al. 2003. EMBO J. 22: 4625-33. PMID: 12970175
3. Ligand-dependent contribution of RXRbeta to cholesterol homeostasis in Sertoli cells.  |  Mascrez, B., et al. 2004. EMBO Rep. 5: 285-90. PMID: 14993927
4. Analysis of ligand-dependent recruitment of coactivator peptides to RXRbeta in a time-resolved fluorescence resonance energy transfer assay.  |  Stafslien, DK., et al. 2007. Mol Cell Endocrinol. 264: 82-9. PMID: 17184907
5. Repression of MHC class I transcription by HPV16E7 through interaction with a putative RXRbeta motif and NF-kappaB cytoplasmic sequestration.  |  Li, H., et al. 2009. Biochem Biophys Res Commun. 388: 383-8. PMID: 19665994
6. Vitamin A Deficiency Decreases the Expression of RARβ and RXRβ/γ in Adult Mouse Brain: Effect of RA Administration.  |  Enderlin, V., et al. 2000. Nutr Neurosci. 3: 173-81. PMID: 27414051
7. The Inhibition of RXRα and RXRβ Receptors Provides Valuable Insights for Potential Prostate Cancer Treatment, in silico Molecular Docking and Molecular Dynamics Studies.  |  Agar, S., et al. 2024. Asian Pac J Cancer Prev. 25: 2329-2335. PMID: 39068565
8. L-thyroxine directly affects expression of thyroid hormone-sensitive genes: regulatory effect of RXRbeta.  |  Bogazzi, F., et al. 1997. Mol Cell Endocrinol. 134: 23-31. PMID: 9406846
9. Vitamin A deficiency and mutations of RXRalpha, RXRbeta and RARalpha lead to early differentiation of embryonic ventricular cardiomyocytes.  |  Kastner, P., et al. 1997. Development. 124: 4749-58. PMID: 9428411
10. Characterization of mouse retinoid X receptor (RXR)-beta gene promoter: negative regulation by tumor necrosis factor (TNF)-alpha.  |  Sugawara, A., et al. 1998. Endocrinology. 139: 3030-3. PMID: 9607817

The preferred RXRα/β/γ antibody is RXRα/β/γ Antibody (F-1): sc-46659.