RRP7A Antibody (B-4): sc-377210

RRP7A Antibody (B-4) is a mouse monoclonal IgG1 kappa light chain antibody that detects RRP7A of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). RRP7A monoclonal antibody (B-4) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. RRP7A, also known as ribosomal RNA processing 7 homolog A, CGI-96, or gastric cancer antigen Zg14, is a 280 amino acid protein characterized by the presence of one RNA recognition motif (RRM) domain, which is crucial for RNA processing and ribosome biogenesis. Proper functioning of RRP7A is essential for ribosomal RNA maturation, a process vital for protein synthesis in cells. Disruptions in RRP7A function can lead to significant cellular dysfunction and are implicated in various diseases, including certain cancers and genetic disorders. RRP7A is encoded by a gene located on human chromosome 22, a region associated with several genetic conditions, including Phelan-McDermid syndrome and Neurofibromatosis type 2. RRP7A′s ability to interact with other proteins involved in RNA processing further underscores RRP7A′s importance in maintaining cellular homeostasis and highlights RRP7A′s potential as a target for therapeutic intervention in related diseases.

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RRP7A Antibody (B-4) References:

1. Disease genes and chromosomes: disease maps of the human genome. Chromosome 22.  |  Gilbert, F. 1998. Genet Test. 2: 89-97. PMID: 10464604
2. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics.  |  Lai, CH., et al. 2000. Genome Res. 10: 703-13. PMID: 10810093
3. Directed proteomic analysis of the human nucleolus.  |  Andersen, JS., et al. 2002. Curr Biol. 12: 1-11. PMID: 11790298
4. Constitutional rearrangements of chromosome 22 as a cause of neurofibromatosis 2.  |  Tsilchorozidou, T., et al. 2004. J Med Genet. 41: 529-34. PMID: 15235024
5. Analyses of the associations between the genes of 22q11 deletion syndrome and schizophrenia.  |  Arinami, T. 2006. J Hum Genet. 51: 1037-1045. PMID: 16969581
6. Identification of four genes required for mammalian blastocyst formation.  |  Maserati, M., et al. 2014. Zygote. 22: 331-9. PMID: 23211737
7. Arabidopsis RIBOSOMAL RNA PROCESSING7 Is Required for 18S rRNA Maturation.  |  Micol-Ponce, R., et al. 2018. Plant Cell. 30: 2855-2872. PMID: 30361235
8. RRP7A links primary microcephaly to dysfunction of ribosome biogenesis, resorption of primary cilia, and neurogenesis.  |  Farooq, M., et al. 2020. Nat Commun. 11: 5816. PMID: 33199730
9. Identification of KRAS mutation in a patient with linear nevus sebaceous syndrome: a case report.  |  Pan, C., et al. 2020. BMC Med Genomics. 13: 188. PMID: 33308209
10. A stop-gain mutation in GXYLT1 promotes metastasis of colorectal cancer via the MAPK pathway.  |  Peng, L., et al. 2022. Cell Death Dis. 13: 395. PMID: 35459861
11. Association of Predicted Expression and Multimodel Association Analysis of Substance Abuse Traits.  |  Bost, DM., et al. 2022. Complex Psychiatry. 8: 35-46. PMID: 36407771
12. Identification of critical genes and drug repurposing targets in entorhinal cortex of Alzheimer's disease.  |  Hosseinpouri, A., et al. 2025. Neurogenetics. 26: 27. PMID: 39928227

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-RRP7A Antibody (B-4) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-RRP7A Antibody (B-4) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

RRP7A Antibody (B-4) Specifications

Alternate Product Name: RRP7A

Product Clone Name: B-4

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 1-280

Epitope Target: RRP7A

Epitope Species: human

Product Reactivity/Detection: RRP7A

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for RRP7A Antibody (B-4): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin, X: TransCruz Reagent