Date published: 2025-10-22

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RRP7A Inhibitors

RRP7A inhibitors represent a class of small molecules designed to target a specific cellular component involved in ribosome biogenesis and maintenance. Ribosomes are fundamental cellular structures responsible for protein synthesis, and their proper assembly and function are crucial for various cellular processes. RRP7A is a key protein component within the small ribosomal subunit (40S) that plays a pivotal role in ribosome assembly and maturation. It is integral for processing ribosomal RNA (rRNA), one of the essential building blocks of ribosomes, and ensuring the accurate formation of functional ribosomes. The inhibition of RRP7A disrupts these intricate processes, leading to impaired ribosome biogenesis.

RRP7A inhibitors exert their effects by specifically binding to the RRP7A protein or interfering with the associated molecular machinery. This disruption primarily occurs at the level of ribosomal RNA processing, where RRP7A is essential for cleavage and modification events crucial for the maturation of small ribosomal subunits. By inhibiting RRP7A, these molecules hinder the proper assembly of 40S ribosomal subunits, consequently impairing ribosome biogenesis. This disruption in ribosome formation can have significant downstream consequences, potentially leading to altered protein synthesis and, in some cases, cellular stress responses. The precise mechanisms by which RRP7A inhibitors achieve their inhibitory effects may vary between different compounds within this class, but their shared objective is to perturb the delicate process of ribosome assembly by targeting this critical component. Researchers have been exploring these inhibitors to gain insights into fundamental cellular processes, and while they may have potential implications in various fields, their primary role lies in elucidating the intricacies of ribosome biogenesis and function at the molecular level.

SEE ALSO...

Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Enoxacin

74011-58-8sc-205670
sc-205670A
500 mg
1 g
$39.00
$48.00
2
(2)

Enoxacin inhibits RRP7A by binding to the enzyme's active site, disrupting RNA processing, and ultimately inhibiting ribosome biogenesis.

CX-5461

1138549-36-6sc-507275
5 mg
$240.00
(0)

CX-5461 inhibits RRP7A by blocking RNA polymerase I-mediated transcription, leading to nucleolar stress and inhibition of ribosome biogenesis.

BMH-21

896705-16-1sc-507460
10 mg
$165.00
(0)

BMH-21 disrupts RRP7A function by interfering with RNA processing and ribosomal RNA maturation, thereby inhibiting ribosome assembly.