RPTPα Antibody (C-3): sc-133070

RPTPα Antibody (C-3) is a mouse monoclonal IgG1 antibody that detects receptor protein-tyrosine phosphatase α (RPTPα) in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). RPTPα plays a crucial role in cellular signaling by dephosphorylating and activating Src family tyrosine kinases, which are essential for regulating integrin signaling, cell adhesion, and growth factor responsiveness. RPTPα is located in the cell membrane, where RPTPα contains an extracellular domain, a single transmembrane segment, and two tandem intracytoplasmic catalytic domains, allowing RPTPα to form constitutive dimers that enhance functional capacity. The human RPTPα sequence encodes a 793 amino acid protein, and in mouse models, RPTPα is known to be constitutively phosphorylated at Ser 180 and Ser 204, which may influence activity and interactions. Additionally, RPTPα serves as a receptor for the Helicobacter pylori vacuolating cytotoxin, VacA, highlighting RPTPα′s importance in both normal cellular functions and pathogenic processes. Anti-RPTPα antibody (C-3) is an invaluable tool for researchers studying the intricate signaling pathways involving this critical protein.

The preferred RPTPα antibody is RPTPα Antibody (H-4): sc-398203.