RORγ Antibody (27.92): sc-293150

RORγ Antibody (27.92) is a mouse monoclonal IgG1 antibody that detects RORγ in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). RORγ, a member of the nuclear hormone receptor superfamily, plays a crucial role in regulating gene expression and is particularly important in the immune system and metabolic processes. RORγ is primarily located in the nucleus, where RORγ functions as a transcription factor, binding to specific DNA sequences known as hormone response elements. Nuclear localization of RORγ is vital for modulating the expression of genes involved in T helper cell differentiation and circadian rhythm regulation. RORγ is highly expressed in skeletal muscle and has been implicated in various physiological processes, including the regulation of inflammatory responses and the development of autoimmune diseases. The gene encoding RORγ is located on chromosome 1q21.3, and RORγ′s unique ability to function as a monomer distinguishes RORγ from other family members, which typically form dimers. RORγ′s potential interaction with ligands such as melatonin further underscores RORγ′s significance in cellular signaling pathways, making anti-RORγ antibody (27.92) an essential tool for researchers studying these diverse biological functions.

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RORγ Antibody (27.92) References:

1. Role of the nuclear hormone receptor ROR gamma in transcriptional regulation, thymocyte survival, and lymphoid organogenesis.  |  Littman, DR., et al. 1999. Cold Spring Harb Symp Quant Biol. 64: 373-81. PMID: 11232310
2. The therapeutic potential of RORγ modulators in the treatment of human disease.  |  Chang, MR., et al. 2012. J Exp Pharmacol. 4: 141-8. PMID: 27186126
3. Endogenously produced nonclassical vitamin D hydroxy-metabolites act as 'biased' agonists on VDR and inverse agonists on RORα and RORγ.  |  Slominski, AT., et al. 2017. J Steroid Biochem Mol Biol. 173: 42-56. PMID: 27693422
4. Combating Autoimmune Diseases With Retinoic Acid Receptor-Related Orphan Receptor-γ (RORγ or RORc) Inhibitors: Hits and Misses.  |  Pandya, VB., et al. 2018. J Med Chem. 61: 10976-10995. PMID: 30010338
5. RORγ is a context-specific master regulator of cholesterol biosynthesis and an emerging therapeutic target in cancer and autoimmune diseases.  |  Zou, H., et al. 2022. Biochem Pharmacol. 196: 114725. PMID: 34384758
6. Therapeutic targeting RORγ with natural product N-hydroxyapiosporamide for small cell lung cancer by reprogramming neuroendocrine fate.  |  Chen, J., et al. 2022. Pharmacol Res. 178: 106160. PMID: 35259480
7. An inhibitor of RORγ for chronic pulmonary obstructive disease treatment.  |  Desai, H., et al. 2022. Sci Rep. 12: 8744. PMID: 35610240
8. Statistical Analysis of Protein-Ligand Interaction Patterns in Nuclear Receptor RORγ.  |  Pham, B., et al. 2022. Front Mol Biosci. 9: 904445. PMID: 35782874
9. Discovery of the First-in-Class RORγ Covalent Inhibitors for Treatment of Castration-Resistant Prostate Cancer.  |  Fang, W., et al. 2024. J Med Chem. 67: 1481-1499. PMID: 38227771
10. Discovery of RORγ Allosteric Fluorescent Probes and Their Application: Fluorescence Polarization, Screening, and Bioimaging.  |  Yu, YC., et al. 2024. J Med Chem. 67: 4194-4224. PMID: 38442261

The preferred RORγ antibody is RORγ Antibody (D-4): sc-365476.