Anti-RORγ Antibody (D-4) is a mouse monoclonal IgG1 (kappa light chain) RORγ antibody provided at 200 µg/ml
raised against amino acids 131-320 mapping within an internal region of RORγ of human origin
ROR gamma Antibody (D-4) is recommended for detection of RORγ of human origin by WB, IP, IF and ELISA
Anti-ROR gamma Antibody (D-4) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
TransCruz reagent for ChIP application (sc-365476 X, 200 µg/0.1 ml)
See m-IgGκ BP-HRP (mouse IgGκ binding protein-HRP), our highly recommended recombinant alternative to conventional secondary anti-mouse IgG reagents.
Contact our Technical Service Department (or your local Distributor) for more information on how to receive a FREE 10 µg sample of RORγ (D-4): sc-365476.
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Labware ships FedEx Ground free of charge to the contiguous US
RORγ Antibody (D-4) is a high quality monoclonal ROR gamma antibody (also designated RORγ antibody) suitable for the detection of the ROR gamma protein of human origin. RORγ Antibody (D-4) is available as both the non-conjugated anti-ROR gamma antibody form, as well as multiple conjugated forms of anti-ROR gamma antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. The nuclear orphan receptors RORα and RORγ are members of the nuclear hormone receptor superfamily. This family acts by directly associating with DNA sequences known as hormone response elements (HREs) and typically bind DNA as either homo- or heterodimers. RORα and RORγ are unique in that they bind DNA as monomers. RORα has multiple isoforms that share common DNA and putative ligand-binding domains, but differ in their amino terminal domains, which are generated by alternative RNA processing. RORγ comprises a 560 amino acid protein that shares 50% amino acid identity with RORα and is most highly expressed in skeletal muscle. Although these proteins are considered "orphan receptors," due to a lack of defined ligands, experimental evidence has shown that melatonin may be the natural ligand for these nuclear receptors. The gene encoding RORα maps to chromosome 15q22.2 and the gene encoding RORγ maps to chromosome 1q21.3.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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