Rock-1 Antibody (H-11): sc-365628
- Rock-1 Antibody (H-11) is a mouse monoclonal IgG1 κ, cited in 9 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 1327-1354 at the C-terminus of Rock-1 of human origin
- recommended for detection of Rock-1 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including and canine and porcine
- See Rock-1 (G-6): sc-17794 for Rock-1 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for Rock-1 Antibody (H-11) for WB applications. These reagents are now offered in bundles with Rock-1 Antibody (H-11) (see ordering information below).
Rock-1 Antibody (H-11) is a mouse monoclonal IgG1 kappa light chain antibody designed to recognize Rho-associated, coiled-coil containing protein kinase 1 (Rock-1), across multiple species including mouse, rat, human, canine, and porcine. Rock-1 monoclonal antibody (H-11) targets a precise epitope within amino acids 1327-1354 at the C-terminus of the human Rock-1 protein, ensuring robust detection in applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Rock-1 is a crucial serine/threonine kinase involved in the regulation of actin cytoskeleton dynamics, influencing the formation of stress fibers, focal adhesions, and the contractile ring, which are essential for processes like cytokinesis and cell migration. Additionally, Rock-1 undergoes post-translational modifications, including phosphorylation, which are vital for its activation, subcellular localization, and interaction with downstream effectors, thereby playing a significant role in cellular signaling pathways that govern cell shape, movement, and proliferation. By modulating these pathways, Rock-1 is implicated in various physiological and pathological processes, making Rock-1 a key target for research in areas such as cancer metastasis, cardiovascular diseases, and neurological disorders. Rock-1 (H-11) antibody facilitates the detailed study of these mechanisms by providing reliable and consistent detection of Rock-1 in diverse experimental settings. Understanding the post-translational modifications of Rock-1 can lead to insights into the regulation of cytoskeletal dynamics and the development of targeted therapies, making Rock-1 (H-11) monoclonal antibody an essential tool for researchers investigating the intricate roles of Rock-1 in cellular function and disease progression.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Rock-1 Antibody (H-11) | sc-365628 | 200 µg/ml | $316.00 | |||
Rock-1 Antibody (H-11): m-IgG Fc BP-HRP Bundle | sc-540356 | 200 µg Ab; 10 µg BP | $354.00 | |||
Rock-1 Antibody (H-11): m-IgG1 BP-HRP Bundle | sc-542063 | 200 µg Ab; 20 µg BP | $354.00 | |||
Rock-1 (H-11) Neutralizing Peptide | sc-365628 P | 100 µg/0.5 ml | $68.00 |