RNase Z1 Antibody (E-5): sc-390029

RNase Z1 Antibody (E-5) is a mouse monoclonal IgG2a kappa light chain antibody that detects RNase Z1 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). RNase Z1 (E-5) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. RNase Z1, also known as ELAC1 or D29, is a 363 amino acid nuclear protein belonging to the RNase Z family of RNA-processing enzymes. RNase Z1 shows predominant expression in lung, brain, placenta, heart, liver, kidney, and pancreas, highlighting essential roles in various tissues. RNase Z1 functions primarily as a zinc phosphodiesterase, crucial for tRNA maturation by removing 3′-trailer segments from precursor tRNA, which is vital for proper tRNA function in protein synthesis. RNase Z1 participates in several other zinc-dependent RNA processing activities, including generating 3′ termini on tRNA, endonucleolytic cleavage of RNA, and removal of extra 3′ nucleotides from unprocessed tRNA. Defects in RNase Z1 have been implicated in prostate cancer pathogenesis, suggesting a significant role in carcinogenesis and highlighting potential as a therapeutic target.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

RNase Z1 Antibody (E-5) References:

1. A candidate prostate cancer susceptibility gene at chromosome 17p.  |  Tavtigian, SV., et al. 2001. Nat Genet. 27: 172-80. PMID: 11175785
2. Physical and transcriptional map of a 311-kb segment of chromosome 18q21, a candidate lung tumor suppressor locus.  |  Yanaihara, N., et al. 2001. Genomics. 72: 169-79. PMID: 11401430
3. Assigning a function to a conserved group of proteins: the tRNA 3'-processing enzymes.  |  Schiffer, S., et al. 2002. EMBO J. 21: 2769-77. PMID: 12032089
4. A candidate prostate cancer susceptibility gene encodes tRNA 3' processing endoribonuclease.  |  Takaku, H., et al. 2003. Nucleic Acids Res. 31: 2272-8. PMID: 12711671
5. Characterization of an Escherichia coli elaC deletion mutant.  |  Schilling, O., et al. 2004. Biochem Biophys Res Commun. 320: 1365-73. PMID: 15303284
6. The role of peptide motifs in the evolution of a protein network.  |  Saito, H., et al. 2007. Nucleic Acids Res. 35: 6357-66. PMID: 17881369
7. Localization of human RNase Z isoforms: dual nuclear/mitochondrial targeting of the ELAC2 gene product by alternative translation initiation.  |  Rossmanith, W. 2011. PLoS One. 6: e19152. PMID: 21559454
8. Colorectal cancer risk and patients' survival: influence of polymorphisms in genes somatically mutated in colorectal tumors.  |  Huhn, S., et al. 2014. Cancer Causes Control. 25: 759-69. PMID: 24706189
9. Genetic variants are major determinants of CSF antibody levels in multiple sclerosis.  |  Goris, A., et al. 2015. Brain. 138: 632-43. PMID: 25616667
10. Gene-by-Diet Interactions Affect Serum 1,25-Dihydroxyvitamin D Levels in Male BXD Recombinant Inbred Mice.  |  Fleet, JC., et al. 2016. Endocrinology. 157: 470-81. PMID: 26587785
11. RNA-Binding Proteins CLK1 and POP7 as Biomarkers for Diagnosis and Prognosis of Esophageal Squamous Cell Carcinoma.  |  Yang, X., et al. 2021. Front Cell Dev Biol. 9: 715027. PMID: 34568328
12. Genes for tRNA recycling are upregulated in response to infection with Theiler's mouse encephalitis virus.  |  Seki, M., et al. 2022. Biochem Biophys Res Commun. 587: 63-68. PMID: 34864548

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-RNase Z1 Antibody (E-5) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-RNase Z1 Antibody (E-5) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

RNase Z1 Antibody (E-5) Specifications

Alternate Product Name: RNase Z1

Product Clone Name: E-5

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 161-270

Epitope Target: RNase Z1

Epitope Species: human

Product Reactivity/Detection: RNase Z1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for RNase Z1 Antibody (E-5): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin, X: TransCruz Reagent