RIP5 Antibody (E-6): sc-374487
- RIP5 Antibody (E-6) is a mouse monoclonal IgG2b κ RIP5 antibody, cited in 2 publications, provided at 200 µg/ml
- raised against amino acids 630-929 mapping at the C-terminus of RIP5 of human origin
- RIP5 Antibody (E-6) is recommended for detection of RIP5 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-RIP5 Antibody (E-6) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for RIP5 Antibody (E-6) for WB and IHC(P) applications. These reagents are now offered in bundles with RIP5 Antibody (E-6) (see ordering information below).
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RIP5 Antibody (E-6) is a mouse monoclonal IgG2b kappa light chain antibody that detects RIP5 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). RIP5 (E-6) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. RIP5 protein, also known as receptor interacting protein kinase 5 (RIPK5), plays a crucial role in cellular signaling pathways, particularly in the regulation of apoptosis and cell survival. RIPK5 is a 929 amino acid protein that contains a protein kinase domain and is primarily localized in the cytoplasm. RIPK5′s importance lies in its ability to catalyze the ATP-dependent phosphorylation of target proteins, which is essential for modulating various cellular functions, including cell division and homeostasis. Additionally, RIPK5 is known to interact with other proteins involved in cell death pathways, further underscoring its significance in maintaining cellular integrity. Expressed at low levels in tissues such as the placenta, heart, brain, kidney, pancreas, testis, and skeletal muscle, RIPK5 has four isoforms resulting from alternative splicing, which may contribute to its diverse functional roles in different cellular contexts.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
RIP5 Antibody (E-6) References:
- RIP5 is a RIP-homologous inducer of cell death. | Zha, J., et al. 2004. Biochem Biophys Res Commun. 319: 298-303. PMID: 15178406
- Dusty protein kinases: primary structure, gene evolution, tissue specific expression and unique features of the catalytic domain. | Peng, J., et al. 2006. Biochim Biophys Acta. 1759: 562-72. PMID: 17123648
- Protein kinase classification. | Hunter, T. 1991. Methods Enzymol. 200: 3-37. PMID: 1835513
- Protein kinase catalytic domain sequence database: identification of conserved features of primary structure and classification of family members. | Hanks, SK. and Quinn, AM. 1991. Methods Enzymol. 200: 38-62. PMID: 1956325
- The protein kinase family: conserved features and deduced phylogeny of the catalytic domains. | Hanks, SK., et al. 1988. Science. 241: 42-52. PMID: 3291115
- Sequence patterns in protein kinases. | Bairoch, A. and Claverie, JM. 1988. Nature. 331: 22. PMID: 3340146
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
RIP5 Antibody (E-6) | sc-374487 | 200 µg/ml | $316.00 | |||
RIP5 Antibody (E-6): m-IgG Fc BP-HRP Bundle | sc-529755 | 200 µg Ab; 10 µg BP | $354.00 | |||
RIP5 Antibody (E-6): m-IgGκ BP-HRP Bundle | sc-522755 | 200 µg Ab, 40 µg BP | $354.00 | |||
RIP5 Antibody (E-6): m-IgG2b BP-HRP Bundle | sc-550142 | 200 µg Ab; 10 µg BP | $354.00 | |||
RIP5 Antibody (E-6) AC | sc-374487 AC | 500 µg/ml, 25% agarose | $416.00 | |||
RIP5 Antibody (E-6) HRP | sc-374487 HRP | 200 µg/ml | $316.00 | |||
RIP5 Antibody (E-6) FITC | sc-374487 FITC | 200 µg/ml | $330.00 | |||
RIP5 Antibody (E-6) PE | sc-374487 PE | 200 µg/ml | $343.00 | |||
RIP5 Antibody (E-6) Alexa Fluor® 488 | sc-374487 AF488 | 200 µg/ml | $357.00 | |||
RIP5 Antibody (E-6) Alexa Fluor® 546 | sc-374487 AF546 | 200 µg/ml | $357.00 | |||
RIP5 Antibody (E-6) Alexa Fluor® 594 | sc-374487 AF594 | 200 µg/ml | $357.00 | |||
RIP5 Antibody (E-6) Alexa Fluor® 647 | sc-374487 AF647 | 200 µg/ml | $357.00 | |||
RIP5 Antibody (E-6) Alexa Fluor® 680 | sc-374487 AF680 | 200 µg/ml | $357.00 | |||
RIP5 Antibody (E-6) Alexa Fluor® 790 | sc-374487 AF790 | 200 µg/ml | $357.00 |