Ribosomal Protein L22 Antibody (D-7): sc-373993

Ribosomal Protein L22 Antibody (D-7) is a mouse monoclonal IgG1 kappa light chain antibody that detects Ribosomal Protein L22 (RPL22) of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). RPL22 antibody (D-7) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. RPL22, also known as heparin-binding protein HBp15, plays a crucial role in ribosome assembly and function, being involved in heparin binding in the submandibular gland and brain. RPL22 associates with two small nuclear RNAs called EBERs (Epstein-Barr encoded RNAs), produced in large quantities by human B lymphocytes infected with Epstein-Barr virus (EBV). RPL22′s structure features a globular domain that interacts with the large ribosomal subunit and an extended loop that penetrates its core, making contact with multiple domains of 23S rRNA. This interaction suggests a potential role in rRNA folding during ribosomal assembly, essential for proper ribosome function in protein synthesis.

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Ribosomal Protein L22 Antibody (D-7) References:

1. Frederick Douglass, Portrait of a black militant. A study in the family romance.  |  Weissman, SM. 1975. Psychoanal Study Child. 30: 725-51. PMID: 1105621
2. Crystals of a mutant form of ribosomal protein L22 rendering bacterial ribosomes resistant to erythromycin.  |  Davydova, N., et al. 2001. Acta Crystallogr D Biol Crystallogr. 57: 1150-2. PMID: 11468402
3. L22 ribosomal protein and effect of its mutation on ribosome resistance to erythromycin.  |  Davydova, N., et al. 2002. J Mol Biol. 322: 635-44. PMID: 12225755
4. Emergence of a Streptococcus pneumoniae isolate resistant to streptogramins by mutation in ribosomal protein L22 during pristinamycin therapy of pneumococcal pneumonia.  |  Cattoir, V., et al. 2007. J Antimicrob Chemother. 59: 1010-2. PMID: 17434877
5. Silencing Ribosomal Protein L22 Promotes Proliferation and Migration, and Inhibits Apoptosis of Gastric Cancer Cells by Regulating the Murine Double Minute 2-Protein 53 (MDM2-p53) Signaling Pathway.  |  Sun, Z., et al. 2021. Med Sci Monit. 27: e928375. PMID: 34050122
6. Assembly of ribosomal subunits affected in a ribosomal mutant of E. coli having an altered L22 protein.  |  Pardo, D., et al. 1979. Mol Gen Genet. 174: 53-8. PMID: 384161
7. In vitro selection of RNA ligands for the ribosomal L22 protein associated with Epstein-Barr virus-expressed RNA by using randomized and cDNA-derived RNA libraries.  |  Dobbelstein, M. and Shenk, T. 1995. J Virol. 69: 8027-34. PMID: 7494316
8. Ribosomal protein L22 from Thermus thermophilus: sequencing, overexpression and crystallisation.  |  Davydova, NL., et al. 1995. FEBS Lett. 369: 229-32. PMID: 7649262
9. Xenopus laevis ribosomal protein L22: full-length cDNA sequence and expression analysis.  |  Rapanotti, MC., et al. 1995. Gene. 154: 199-203. PMID: 7890164
10. The primary structure of rat ribosomal protein L22.  |  Chan, YL. and Wool, IG. 1995. Biochim Biophys Acta. 1260: 113-5. PMID: 7999786
11. A novel heparin-binding protein, HBp15, is identified as mammalian ribosomal protein L22.  |  Fujita, Y., et al. 1994. Biochem Biophys Res Commun. 199: 706-13. PMID: 8135813
12. The crystal structure of ribosomal protein L22 from Thermus thermophilus: insights into the mechanism of erythromycin resistance.  |  Unge, J., et al. 1998. Structure. 6: 1577-86. PMID: 9862810

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Ribosomal Protein L22 Antibody (D-7) has 7 citations in a variety of scientific publications.

Primary antibodies like Anti-Ribosomal Protein L22 Antibody (D-7) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Ribosomal Protein L22 Antibody (D-7) Specifications

Alternate Product Name: Ribosomal Protein L22

Product Clone Name: D-7

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 17-122

Epitope Target: Ribosomal Protein L22

Epitope Species: human

Product Reactivity/Detection: Ribosomal Protein L22

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 7 citations in various scientific publications

Available Conjugates/Forms for Ribosomal Protein L22 Antibody (D-7): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin

The preferred Ribosomal Protein L22 antibody is Ribosomal Protein L22 Antibody (52): sc-136413.