Ribosomal Protein L22 Antibody (52): sc-136413

Ribosomal Protein L22 Antibody (52) is a mouse monoclonal IgG1 kappa light chain antibody that detects Ribosomal Protein L22 in mouse, rat, human, and canine samples through western blotting (WB) and immunoprecipitation (IP). Anti-Ribosomal Protein L22 antibody (52) is available in both conjugated and non-conjugated forms, providing flexibility for various experimental needs. Ribosomal Protein L22, also known as heparin-binding protein HBp15, plays a crucial role in ribosomal function and protein synthesis, as Ribosomal Protein L22 is integral to the ribosome structure. Ribosomal Protein L22 interacts with two small nuclear RNAs, EBERs (Epstein-Barr encoded RNAs), which are produced in large quantities by human B lymphocytes infected with Epstein-Barr virus (EBV). Ribosomal Protein L22′s presence in the ribosomal subunit, characterized by a globular domain and extended loop, suggests a potential role in ribosomal RNA folding during assembly, although Ribosomal Protein L22 is not essential for this process. Understanding Ribosomal Protein L22′s function and interactions helps reveal mechanisms of ribosome assembly and viral infections′ impact on cellular processes.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Ribosomal Protein L22 Antibody (52) References:

1. Ribosomal protein L22 inhibits regulation of cellular activities by the Epstein-Barr virus small RNA EBER-1.  |  Elia, A., et al. 2004. Eur J Biochem. 271: 1895-905. PMID: 15128299
2. Clusters of basic amino acids contribute to RNA binding and nucleolar localization of ribosomal protein L22.  |  Houmani, JL. and Ruf, IK. 2009. PLoS One. 4: e5306. PMID: 19390581
3. Growth-promoting properties of Epstein-Barr virus EBER-1 RNA correlate with ribosomal protein L22 binding.  |  Houmani, JL., et al. 2009. J Virol. 83: 9844-53. PMID: 19640998
4. Inactivation of ribosomal protein L22 promotes transformation by induction of the stemness factor, Lin28B.  |  Rao, S., et al. 2012. Blood. 120: 3764-73. PMID: 22976955
5. Down-regulation of ribosomal protein L22 in non-small cell lung cancer.  |  Yang, M., et al. 2013. Med Oncol. 30: 646. PMID: 23797773
6. Interaction of ribosomal protein L22 with casein kinase 2α: a novel mechanism for understanding the biology of non-small cell lung cancer.  |  Yang, M., et al. 2014. Oncol Rep. 32: 139-44. PMID: 24840952
7. Ribosomal protein L22-like1 (RPL22L1) mediates sorafenib sensitivity via ERK in hepatocellular carcinoma.  |  Zhang, D., et al. 2022. Cell Death Discov. 8: 365. PMID: 35973992
8. Ribosomal protein L22-like1 promotes prostate cancer progression by activating PI3K/Akt/mTOR signalling pathway.  |  Yi, X., et al. 2023. J Cell Mol Med. 27: 403-411. PMID: 36625246
9. The ribosomal protein L22 binds the MDM4 pre-mRNA and promotes exon skipping to activate p53 upon nucleolar stress.  |  Jansen, J., et al. 2024. Cell Rep. 43: 114610. PMID: 39116201
10. Knockdown of ribosomal protein L22-like 1 arrests the cell cycle and promotes apoptosis in colorectal cancer.  |  Li, C., et al. 2024. Cytojournal. 21: 45. PMID: 39737125

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Ribosomal Protein L22 Antibody (52) has 7 citations in a variety of scientific publications.

Primary antibodies like Anti-Ribosomal Protein L22 Antibody (52) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Ribosomal Protein L22 Antibody (52) Specifications

Alternate Product Name: Ribosomal Protein L22

Product Clone Name: 52

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 18-120

Epitope Target: Ribosomal Protein L22

Epitope Species: human

Product Reactivity/Detection: Ribosomal Protein L22

Species Reactivity/Detection: mouse, rat, human, canine

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 7 citations in various scientific publications

Available Conjugates/Forms for Ribosomal Protein L22 Antibody (52): AC: Agarose, HRP: Horseradish Peroxidase

The preferred Ribosomal Protein L22 antibody is Ribosomal Protein L22 Antibody (D-7): sc-373993.