Rhodanese Antibody (E-11): sc-365562

Rhodanese Antibody (E-11) is a mouse monoclonal IgG1 antibody that detects rhodanese in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Rhodanese, also known as thiosulfate sulfurtransferase, is a crucial mitochondrial matrix enzyme encoded by nuclear DNA, consisting of 297 amino acids. Anti-rhodanese antibody (E-11) plays a vital role in studying this enzyme′s function of detoxifying cyanide by converting it into less harmful thiocyanate, which is essential for cellular protection against cyanide toxicity. Additionally, rhodanese is involved in the formation of iron-sulfur proteins and the modification of sulfur-containing enzymes, highlighting its importance in various metabolic processes. The enzyme was first identified in human red blood cells in 1956 and has been crystallized from beef liver, providing insights into its structure and function. Notably, a deficiency in rhodanese activity has been linked to Leber′s optic neuropathy, a hereditary condition that can lead to vision loss, emphasizing the clinical significance of this protein. The gene encoding rhodanese is located on human chromosome 22q11.2-qter, and the red cell and tissue forms of rhodanese are determined by separate genes, suggesting a complex regulation of its expression across different tissues. Rhodanese monoclonal antibody (E-11) serves as an invaluable tool for researchers studying the biochemical pathways involving this enzyme and its implications in human health.

The preferred Rhodanese antibody is Rhodanese Antibody (G-7): sc-271883.