Rho GDIα Antibody (B-10): sc-13120
- Rho GDIα Antibody (B-10) is a mouse monoclonal IgG2b κ, cited in 7 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 178-198 at the C-terminus of Rho GDIα of human origin
- recommended for detection of Rho GDIα of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA; also reactive with additional species, including and equine and canine
- available conjugated to agarose for IP
- m-IgG Fc BP-HRP, m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Rho GDIα Antibody (B-10) for WB and IHC(P) applications. These reagents are now offered in bundles with Rho GDIα Antibody (B-10) (see ordering information below).
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Rho GDIα Antibody (B-10) is a mouse monoclonal IgG2b antibody that detects Rho GDIα in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Rho GDIα, also known as ARHGDIA or GDIA1, is a 204 amino acid protein that plays a crucial role in regulating the activity of Rho proteins, which are essential for various cellular processes such as cell migration, adhesion, and cytoskeletal dynamics. By sequestering Rho proteins in their inactive GDP-bound state, Rho GDIα prevents their activation, thereby modulating signaling pathways that influence cell behavior. The importance of Rho GDIα is further underscored by its ability to undergo post-translational modifications, such as phosphorylation at Ser 101 by p21-activated kinase (αPAK), which can inhibit its activity and lead to a positive feedback loop that enhances the signaling of certain Rho GDIα target proteins. This regulatory mechanism highlights the significance of Rho GDIα in maintaining cellular homeostasis and its potential implications in various diseases, including cancer, where Rho signaling is often dysregulated. Anti-Rho GDIα antibody (B-10) is an invaluable tool for researchers aiming to explore the intricate roles of Rho proteins in cellular signaling and their contributions to physiological and pathological processes.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Rho GDIα Antibody (B-10) | sc-13120 | 200 µg/ml | $322.00 | |||
Rho GDIα Antibody (B-10): m-IgG Fc BP-HRP Bundle | sc-536572 | 200 µg Ab; 10 µg BP | $361.00 | |||
Rho GDIα Antibody (B-10): m-IgGκ BP-HRP Bundle | sc-533723 | 200 µg Ab; 40 µg BP | $361.00 | |||
Rho GDIα Antibody (B-10): m-IgG2b BP-HRP Bundle | sc-549812 | 200 µg Ab; 10 µg BP | $361.00 | |||
Rho GDIα Antibody (B-10) AC | sc-13120 AC | 500 µg/ml, 25% agarose | $424.00 | |||
Rho GDIα (B-10) Neutralizing Peptide | sc-13120 P | 100 µg/0.5 ml | $69.00 |