RhC Antibody (109): sc-52431
- RhC Antibody (109) is a mouse monoclonal IgM RhC antibody provided at 100 µg/ml
- raised against Rhesus blood group C antigen of human origin
- recommended for detection of Rhesus blood group C antigen of human origin by WB, IP, IF and FCM
- available conjugated to FITC for IF, IHC(P) and FCM
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for RhC Antibody (109). This work is in progress.
RhC Antibody (109) is a mouse monoclonal IgM antibody that detects the RhC protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM). RhC (109) antibody is available in both non-conjugated and various conjugated forms, including fluorescein isothiocyanate (FITC), providing versatility for different experimental needs. RhC protein plays a crucial role in the Rhesus (Rh) blood group system, which is one of the most complex and significant blood group systems in humans. The Rh blood group antigens are encoded by two highly homologous genes, RHD and RHCE, located on chromosome 1p34.1-1p36. RHD gene is particularly noteworthy as RHD encodes the D antigen, the most potent blood group immunogen, and RHD deletion in a significant portion of the population can lead to Rh incompatibility issues during pregnancy, resulting in hemolytic disease of the newborn (HDN). RHCE gene has four allelic forms that determine the expression of various antigen combinations, including Ce, ce, cE, and CE. RhC protein is an integral membrane protein characterized by 12 transmembrane helices, which are essential for maintaining erythrocyte membrane integrity. The antigenic activity of Rh proteins requires a complex formation between RHCED antigens and RHAG (RH50), highlighting the intricate interactions necessary for proper blood group function and potential implications in transfusion medicine and prenatal care.
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RhC Antibody (109) References:
- RHD gene deletion occurred in the Rhesus box. | Wagner, FF. and Flegel, WA. 2000. Blood. 95: 3662-8. PMID: 10845894
- Haemolytic disease of newborn. | Narang, A. and Jain, N. 2001. Indian J Pediatr. 68: 167-72. PMID: 11284186
- [Molecular genetics and clinical application of Rh blood group system]. | Zhang, J., et al. 2002. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 19: 246-9. PMID: 12048689
- Organization of the gene (RHCE) encoding the human blood group RhCcEe antigens and characterization of the promoter region. | Chérif-Zahar, B., et al. 1994. Genomics. 19: 68-74. PMID: 8188244
- Molecular genetic basis of the human Rhesus blood group system. | Mouro, I., et al. 1993. Nat Genet. 5: 62-5. PMID: 8220426
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
RhC Antibody (109) | sc-52431 | 100 µg/ml | $322.00 | |||
RhC Antibody (109) FITC | sc-52431 FITC | 100 tests in 2 ml | $336.00 |