RhC Inhibitors
RhC inhibitors represent a class of chemical compounds that specifically inhibit the activity of RhC, a protein or enzyme involved in essential cellular processes, most notably related to signal transduction and protein interactions. RhC is believed to play a role in maintaining cellular homeostasis by influencing pathways that regulate protein modifications, transport, or localization within cells. These processes can involve mechanisms such as phosphorylation, ubiquitination, or other post-translational modifications that ensure proper cellular functioning. The inhibition of RhC disrupts its ability to carry out these tasks, thus providing a window into the broader effects on the cellular pathways it influences.
The development of RhC inhibitors centers on designing small molecules capable of selectively binding to the active sites or other functional regions of the RhC protein, thus preventing its normal interaction with substrates or regulatory partners. These inhibitors are typically tailored to the protein's unique structural features, such as specific domains that are crucial for its function, which might include binding pockets or enzymatic sites. By blocking these key sites, RhC inhibitors help to unravel the role of RhC in biological systems, allowing researchers to observe changes in cellular pathways and molecular interactions when RhC is inactivated. As a result, RhC inhibitors serve as important tools for the exploration of protein function, regulation of cellular pathways, and the complex molecular interactions that underlie cellular behavior.
Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
α-Amanitin | 23109-05-9 | sc-202440 sc-202440A | 1 mg 5 mg | $260.00 $1029.00 | 26 | |
Directly inhibits RNA polymerase II, leading to decreased transcription of the RHCE gene and subsequent reduction in RhC antigen synthesis. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $73.00 $238.00 $717.00 $2522.00 $21420.00 | 53 | |
Binds to DNA at the transcription initiation complex, obstructing the elongation phase of RNA synthesis and resulting in reduced levels of RHCE mRNA and lower RhC antigen production. | ||||||
Triptolide | 38748-32-2 | sc-200122 sc-200122A | 1 mg 5 mg | $88.00 $200.00 | 13 | |
Reduces the transcription of a broad range of genes by inhibiting transcription factors, leading to a downregulation of RHCE gene transcription and a decrease in RhC antigen levels. | ||||||
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $40.00 $82.00 $256.00 | 127 | |
Inhibits eukaryotic ribosomal translocation steps, leading to a blockade of protein elongation and a decrease in the synthesis of RhC antigen from RHCE mRNA. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Inhibits the mTOR pathway, which can lead to a reduction in cap-dependent translation, potentially decreasing the production of the RhC antigen. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $68.00 | 2 | |
Interferes with the replication and transcription of DNA, potentially leading to a decrease in the transcriptional activity of the RHCE gene and lower production of RhC antigen. | ||||||
DRB | 53-85-0 | sc-200581 sc-200581A sc-200581B sc-200581C | 10 mg 50 mg 100 mg 250 mg | $42.00 $185.00 $310.00 $650.00 | 6 | |
Selectively inhibits the phosphorylation of the carboxy-terminal domain of RNA polymerase II, resulting in the inhibition of mRNA elongation and decreased RhC antigen expression. | ||||||
Rocaglamide | 84573-16-0 | sc-203241 sc-203241A sc-203241B sc-203241C sc-203241D | 100 µg 1 mg 5 mg 10 mg 25 mg | $270.00 $465.00 $1607.00 $2448.00 $5239.00 | 4 | |
Selectively inhibits translation initiation by binding to the eIF4A subunit of the translation initiation complex, potentially leading to a decrease in RhC antigen synthesis. | ||||||
Mycophenolic acid | 24280-93-1 | sc-200110 sc-200110A | 100 mg 500 mg | $68.00 $261.00 | 8 | |
Inhibits inosine monophosphate dehydrogenase, leading to depleted guanosine nucleotides, which can result in the downregulation of RHCE mRNA synthesis and a consequent reduction in RhC antigen levels. | ||||||
Flavopiridol | 146426-40-6 | sc-202157 sc-202157A | 5 mg 25 mg | $78.00 $254.00 | 41 | |
Inhibits cyclin-dependent kinases involved in the regulation of transcription, leading to a reduction in the transcription rate of the RHCE gene and decreased RhC antigen levels. | ||||||