Reg IIIα/γ Antibody (B-10): sc-377038

Reg IIIα/γ Antibody (B-10) is a mouse monoclonal IgG2b kappa light chain antibody that detects Reg III alpha / gamma protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Reg IIIα/γ (B-10) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. The Reg III family of proteins plays a crucial role in regulating cell growth and differentiation, particularly in the pancreas, where Reg IIIγ, also known as regenerating islet-derived 3 gamma, is predominantly expressed. This 175 amino acid secreted protein maintains intestinal homeostasis and acts as an antimicrobial agent, helping to control bacterial proliferation, especially during conditions such as acute pancreatitis. The gene encoding Reg IIIγ is located on human chromosome 2, which contains numerous genes essential for various biological functions. Reg IIIγ′s ability to modulate immune response and involvement in inflammatory processes highlight its importance in both health and disease, making anti-Reg IIIα/γ antibody (B-10) a valuable tool for researchers studying these pathways.

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Reg IIIα/γ Antibody (B-10) References:

1. Reg gene family and human diseases.  |  Zhang, YW., et al. 2003. World J Gastroenterol. 9: 2635-41. PMID: 14669303
2. Molecular cloning, expression and chromosomal localization of a novel human REG family gene, REG III.  |  Nata, K., et al. 2004. Gene. 340: 161-70. PMID: 15556304
3. PAP IB, a new member of the Reg gene family: cloning, expression, structural properties, and evolution by gene duplication.  |  Laurine, E., et al. 2005. Biochim Biophys Acta. 1727: 177-87. PMID: 15777617
4. Symbiotic bacteria direct expression of an intestinal bactericidal lectin.  |  Cash, HL., et al. 2006. Science. 313: 1126-30. PMID: 16931762
5. Pancreatic islet immunoreactivity to the Reg protein INGAP.  |  Taylor-Fishwick, DA., et al. 2008. J Histochem Cytochem. 56: 183-91. PMID: 17998566
6. Vancomycin-resistant enterococci exploit antibiotic-induced innate immune deficits.  |  Brandl, K., et al. 2008. Nature. 455: 804-7. PMID: 18724361
7. REG3α is a novel biomarker that potentially correlates with acute allograft rejection after intestinal transplantation.  |  Smullin, CP., et al. 2021. Clin Transplant. 35: e14378. PMID: 34060679
8. Nociceptor-derived Reg3γ prevents endotoxic death by targeting kynurenine pathway in microglia.  |  Sugisawa, E., et al. 2022. Cell Rep. 38: 110462. PMID: 35263589
9. High-fat diet disrupts REG3γ and gut microbial rhythms promoting metabolic dysfunction.  |  Frazier, K., et al. 2022. Cell Host Microbe. 30: 809-823.e6. PMID: 35439436
10. Reg3α concentrations at day of allogeneic stem cell transplantation predict outcome and correlate with early antibiotic use.  |  Weber, D., et al. 2023. Blood Adv. 7: 1326-1335. PMID: 36350750
11. Amphiregulin, ST2, and REG3α biomarker risk algorithms as predictors of nonrelapse mortality in patients with acute GVHD.  |  Etra, A., et al. 2024. Blood Adv. 8: 3284-3292. PMID: 38640195
12. Structure, chromosomal localization and expression of mouse genes encoding type III Reg, RegIII alpha, RegIII beta, RegIII gamma.  |  Narushima, Y., et al. 1997. Gene. 185: 159-68. PMID: 9055810

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Reg IIIα/γ Antibody (B-10) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-Reg IIIα/γ Antibody (B-10) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Reg IIIα/γ Antibody (B-10) Specifications

Alternate Product Name: Reg IIIα/γ

Product Clone Name: B-10

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 107-175

Epitope Target: Reg IIIα

Epitope Species: human

Product Reactivity/Detection: Reg IIIα and Reg IIIγ

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for Reg IIIα/γ Antibody (B-10): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin

The preferred Reg IIIα antibody is Reg IIIα Antibody (3x1R-7): sc-80319.