Reg IIIα Antibody (3x1R-7): sc-80319

Reg IIIα Antibody (3x1R-7) is a mouse monoclonal IgG2a kappa light chain antibody that detects Reg III alpha protein of mouse and rat origin by western blotting (WB) and enzyme-linked immunosorbent assay (ELISA). Anti-Reg III alpha antibody (3x1R-7) is available as a non-conjugated isotype antibody. Reg III alpha protein, also known as pancreatitis-associated protein, plays a crucial role in immune response and is primarily expressed in the intestine, with notable localization to the apical region of pancreatic acinar cells. Reg III alpha protein is part of the regeneration (REG) family, which consists of secretory proteins involved in proliferation and differentiation of liver, pancreatic, gastric, and intestinal cells. The REG family is divided into four subclasses, and members have been implicated in various biological processes, including cell growth regulation and tumorigenesis. Increased expression of Reg III alpha has been associated with pancreatic inflammation and liver carcinogenesis, highlighting significance in disease progression. Reg III alpha is detected in pancreatic juice during episodes of pancreatic inflammation, making Reg III alpha a valuable biomarker for assessing pancreatic health.

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Reg IIIα Antibody (3x1R-7) References:

1. Molecular cloning, expression and chromosomal localization of a novel human REG family gene, REG III.  |  Nata, K., et al. 2004. Gene. 340: 161-70. PMID: 15556304
2. Differentially expressed transcripts from phenotypically identified olfactory sensory neurons.  |  Yu, TT., et al. 2005. J Comp Neurol. 483: 251-62. PMID: 15682396
3. Opposite roles of human pancreatitis-associated protein and REG1A expression in hepatocellular carcinoma: association of pancreatitis-associated protein expression with low-stage hepatocellular carcinoma, beta-catenin mutation, and favorable prognosis.  |  Yuan, RH., et al. 2005. Clin Cancer Res. 11: 2568-75. PMID: 15814635
4. Morphogenetic plasticity of adult human pancreatic islets of Langerhans.  |  Jamal, AM., et al. 2005. Cell Death Differ. 12: 702-12. PMID: 15818398
5. The value of biliary amylase and Hepatocarcinoma-Intestine-Pancreas/Pancreatitis-associated Protein I (HIP/PAP-I) in diagnosing biliary malignancies.  |  Chen, CY., et al. 2005. Clin Biochem. 38: 520-5. PMID: 15885230
6. Expression of Reg/PAP family members during motor nerve regeneration in rat.  |  Namikawa, K., et al. 2005. Biochem Biophys Res Commun. 332: 126-34. PMID: 15896308
7. HIP/PAP accelerates liver regeneration and protects against acetaminophen injury in mice.  |  Lieu, HT., et al. 2005. Hepatology. 42: 618-26. PMID: 16116631
8. Is it long-term continuous drinking or the post-drinking withdrawal period that triggers the first acute alcoholic pancreatitis?  |  Nordback, I., et al. 2005. Scand J Gastroenterol. 40: 1235-9. PMID: 16265780
9. Overexpression of regenerating islet-derived 1 alpha and 3 alpha genes in human primary liver tumors with beta-catenin mutations.  |  Cavard, C., et al. 2006. Oncogene. 25: 599-608. PMID: 16314847
10. Elevated REG3α predicts refractory aGVHD in patients who received steroids-ruxolitinib as first-line therapy.  |  Yang, J., et al. 2022. Ann Hematol. 101: 621-630. PMID: 34816294
11. Recombinant Reg3α Prevents Islet β-Cell Apoptosis and Promotes β-Cell Regeneration.  |  Yu, L., et al. 2022. Int J Mol Sci. 23: PMID: 36142497
12. Amphiregulin, ST2, and REG3α biomarker risk algorithms as predictors of nonrelapse mortality in patients with acute GVHD.  |  Etra, A., et al. 2024. Blood Adv. 8: 3284-3292. PMID: 38640195

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Reg IIIα Antibody (3x1R-7) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-Reg IIIα Antibody (3x1R-7) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Reg IIIα Antibody (3x1R-7) Specifications

Alternate Product Name: Reg IIIα

Product Clone Name: 3x1R-7

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids:

Epitope Target: Reg IIIα

Epitope Species: rat

Product Reactivity/Detection: Reg IIIα

Species Reactivity/Detection: mouse, rat

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, ELISA

Vialing Information: Each vial contains 100 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and protein stabilizer

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for Reg IIIα Antibody (3x1R-7): N/A

The preferred Reg IIIα/γ antibody is Reg IIIα/γ Antibody (B-10): sc-377038.