REEP1 Antibody (A-8): sc-393242
- REEP1 Antibody (A-8) is a mouse monoclonal IgG1 κ REEP1 antibody, cited in 1 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 145-169 near the C-terminus of REEP1 of human origin
- REEP1 Antibody (A-8) is recommended for detection of REEP1 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-REEP1 Antibody (A-8) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for REEP1 Antibody (A-8) for WB applications. These reagents are now offered in bundles with REEP1 Antibody (A-8) (see ordering information below).
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REEP1 Antibody (A-8) is a mouse monoclonal IgG1 kappa light chain antibody that detects REEP1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). REEP1 (A-8) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. REEP1 protein, a 201 amino acid multi-pass membrane protein located in the mitochondrion, plays a crucial role in the transport of G protein-coupled receptors (GPCRs) to the cell surface membrane, which is essential for effective receptor-ligand recognition. Specifically, REEP1 enhances the cell surface expression of odorant receptors, which are notoriously poorly expressed when heterologously expressed in cells. This function is particularly important in the context of sensory perception, as it directly impacts the ability of organisms to detect and respond to environmental cues. Mutations in the REEP1 gene are associated with hereditary spastic paraplegia, making REEP1 a significant target for research into neurodegenerative disorders. The REEP1 gene is conserved across various species, including chimpanzees, dogs, cows, mice, rats, chickens, zebrafish, Arabidopsis thaliana, and rice, and is located on human chromosome 2p11.2.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
REEP1 Antibody (A-8) References:
- RTP family members induce functional expression of mammalian odorant receptors. | Saito, H., et al. 2004. Cell. 119: 679-91. PMID: 15550249
- Members of RTP and REEP gene families influence functional bitter taste receptor expression. | Behrens, M., et al. 2006. J Biol Chem. 281: 20650-9. PMID: 16720576
- Mutations in the novel mitochondrial protein REEP1 cause hereditary spastic paraplegia type 31. | Züchner, S., et al. 2006. Am J Hum Genet. 79: 365-9. PMID: 16826527
- REEP1 mutation spectrum and genotype/phenotype correlation in hereditary spastic paraplegia type 31. | Beetz, C., et al. 2008. Brain. 131: 1078-86. PMID: 18321925
- New pedigrees and novel mutation expand the phenotype of REEP1-associated hereditary spastic paraplegia (HSP). | Hewamadduma, C., et al. 2009. Neurogenetics. 10: 105-10. PMID: 19034539
- Interstitial deletion 2p11.2-p12: report of a patient with mental retardation and review of the literature. | Tzschach, A., et al. 2009. Am J Med Genet A. 149A: 242-5. PMID: 19161151
- Hereditary spastic paraplegia proteins REEP1, spastin, and atlastin-1 coordinate microtubule interactions with the tubular ER network. | Park, SH., et al. 2010. J Clin Invest. 120: 1097-110. PMID: 20200447
- Mutation screening of spastin, atlastin, and REEP1 in hereditary spastic paraplegia. | McCorquodale, DS., et al. 2011. Clin Genet. 79: 523-30. PMID: 20718791
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
REEP1 Antibody (A-8) | sc-393242 | 200 µg/ml | $316.00 | |||
REEP1 Antibody (A-8): m-IgG Fc BP-HRP Bundle | sc-530403 | 200 µg Ab; 10 µg BP | $354.00 | |||
REEP1 Antibody (A-8): m-IgGκ BP-HRP Bundle | sc-523869 | 200 µg Ab, 40 µg BP | $354.00 | |||
REEP1 Antibody (A-8) AC | sc-393242 AC | 500 µg/ml, 25% agarose | $416.00 | |||
REEP1 Antibody (A-8) HRP | sc-393242 HRP | 200 µg/ml | $316.00 | |||
REEP1 Antibody (A-8) FITC | sc-393242 FITC | 200 µg/ml | $330.00 | |||
REEP1 Antibody (A-8) PE | sc-393242 PE | 200 µg/ml | $343.00 | |||
REEP1 Antibody (A-8) Alexa Fluor® 488 | sc-393242 AF488 | 200 µg/ml | $357.00 | |||
REEP1 Antibody (A-8) Alexa Fluor® 546 | sc-393242 AF546 | 200 µg/ml | $357.00 | |||
REEP1 Antibody (A-8) Alexa Fluor® 594 | sc-393242 AF594 | 200 µg/ml | $357.00 | |||
REEP1 Antibody (A-8) Alexa Fluor® 647 | sc-393242 AF647 | 200 µg/ml | $357.00 | |||
REEP1 Antibody (A-8) Alexa Fluor® 680 | sc-393242 AF680 | 200 µg/ml | $357.00 | |||
REEP1 Antibody (A-8) Alexa Fluor® 790 | sc-393242 AF790 | 200 µg/ml | $357.00 | |||
REEP1 (A-8) Neutralizing Peptide | sc-393242 P | 100 µg/0.5 ml | $68.00 |