REEP1 Inhibitors
Chemical inhibitors of REEP1 target the protein's interaction with microtubules, which are integral to its function in shaping the endoplasmic reticulum. Colchicine disrupts microtubule polymerization, a process essential for the correct localization and interaction of REEP1 with microtubules, thereby inhibiting its function. Vinblastine and Vincristine bind to tubulin, the building block of microtubules, inhibiting their assembly, which in turn inhibits the functionality of REEP1 by disrupting the cytoskeletal framework it associates with. Nocodazole and Podophyllotoxin further contribute to this disruption by inhibiting microtubule polymerization, preventing REEP1 from modulating the microtubule network and the endoplasmic reticulum's architecture.
In continuation, Eribulin selectively inhibits the growth phase of microtubules, altering their dynamics and thereby interfering with the cellular functions of REEP1 related to microtubule interactions. Griseofulvin binds to tubulin, causing a disruption in microtubule function that inhibits the microtubule-dependent functions of REEP1. Albendazole and Mebendazole induce the depolymerization of microtubules, which indirectly inhibits REEP1's role in endoplasmic reticulum organization. Thiabendazole impedes microtubule assembly, which is critical for the function of REEP1, as its ability to modulate the endoplasmic reticulum's structure is closely tied to the integrity of the microtubule network. Lastly, Parbendazole's inhibition of microtubule polymerization can lead to an indirect inhibition of REEP1 by disrupting the microtubule network essential for REEP1's role in mediating the structural dynamics of the endoplasmic reticulum.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Colchicine | 64-86-8 | sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E | 1 g 5 g 50 g 100 g 500 g 1 kg | $100.00 $321.00 $2289.00 $4484.00 $18207.00 $34749.00 | 3 | |
Colchicine can disrupt microtubule polymerization, which is essential for intracellular transport processes. Since REEP1 is involved in shaping the endoplasmic reticulum and microtubule interaction, the disruption of microtubules can inhibit the proper functioning of REEP1 by preventing its correct localization and interaction with microtubules. | ||||||
Vinblastine | 865-21-4 | sc-491749 sc-491749A sc-491749B sc-491749C sc-491749D | 10 mg 50 mg 100 mg 500 mg 1 g | $102.00 $235.00 $459.00 $1749.00 $2958.00 | 4 | |
Vinblastine binds to tubulin and inhibits microtubule formation. As REEP1 is involved in microtubule-dependent processes, the inhibition of microtubule assembly can indirectly inhibit the functionality of REEP1 by disrupting the cytoskeletal framework it associates with. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $59.00 $85.00 $143.00 $247.00 | 38 | |
Nocodazole disrupts microtubule polymerization, which can inhibit the function of REEP1 by interfering with its ability to modulate the microtubule network and the endoplasmic reticulum's architecture, which REEP1 is known to influence. | ||||||
Podophyllotoxin | 518-28-5 | sc-204853 | 100 mg | $84.00 | 1 | |
Podophyllotoxin inhibits the polymerization of microtubules. The inhibition of the microtubule network's proper formation and maintenance can impede the functioning of REEP1, which relies on microtubules for its role in shaping the endoplasmic reticulum. | ||||||
Eribulin | 253128-41-5 | sc-507547 | 5 mg | $865.00 | ||
Eribulin inhibits the growth phase of microtubules without affecting the shortening phase, leading to mitotic blockade. This selective inhibition of microtubule dynamics can interfere with the cellular functions of REEP1 related to microtubule interactions and endoplasmic reticulum morphology. | ||||||
Griseofulvin | 126-07-8 | sc-202171A sc-202171 sc-202171B | 5 mg 25 mg 100 mg | $85.00 $220.00 $598.00 | 4 | |
Griseofulvin disrupts microtubule function by binding to tubulin, which can inhibit the microtubule-dependent functions of REEP1, such as its role in the structural organization of the endoplasmic reticulum. | ||||||
Albendazole | 54965-21-8 | sc-210771 | 100 mg | $213.00 | 1 | |
Albendazole, by causing depolymerization of microtubules, can indirectly inhibit REEP1 function, as REEP1 is associated with the cytoskeletal system and endoplasmic reticulum shaping, both of which are influenced by microtubule dynamics. | ||||||
Mebendazole | 31431-39-7 | sc-204798 sc-204798A | 5 g 25 g | $46.00 $89.00 | 2 | |
Mebendazole disrupts microtubule synthesis, which could inhibit REEP1's role in the endoplasmic reticulum organization and its interaction with the microtubule cytoskeleton, thus inhibiting its function indirectly. | ||||||
Thiabendazole | 148-79-8 | sc-204913 sc-204913A sc-204913B sc-204913C sc-204913D | 10 g 100 g 250 g 500 g 1 kg | $32.00 $84.00 $183.00 $312.00 $572.00 | 5 | |
Thiabendazole interferes with microtubule assembly, which can inhibit the function of REEP1 by obstructing its ability to modulate the microtubule-dependent shaping of the endoplasmic reticulum. | ||||||