RBPMS Antibody (1C12): sc-293285

RBPMS Antibody (1C12) is a mouse monoclonal IgG2a kappa light chain antibody that detects RBPMS protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Anti-RBPMS antibody (1C12) is available as the non-conjugated format. RBPMS, or RNA binding protein with multiple splicing, is a 196 amino acid protein characterized by one RNA recognition motif (RRM) domain, which is crucial for RNA binding function. RBPMS plays a significant role in regulating RNA metabolism, including processes such as splicing, stability, and translation of mRNA, thereby influencing gene expression and cellular function. RBPMS interaction with various RNA molecules makes RBPMS essential for maintaining proper cellular homeostasis and responding to stress conditions. The gene encoding RBPMS is located on human chromosome 8, a region associated with numerous genetic disorders and malignancies, highlighting RBPMS importance in both normal physiology and disease states.

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RBPMS Antibody (1C12) References:

1. The RNA-binding protein gene, hermes, is expressed at high levels in the developing heart.  |  Gerber, WV., et al. 1999. Mech Dev. 80: 77-86. PMID: 10096065
2. Resonance assignments for the N-terminal domain from human RNA-binding protein with multiple splicing (RBP-MS).  |  Sahasrabudhe, PV., et al. 2001. J Biomol NMR. 19: 285-6. PMID: 11330819
3. An unappreciated role for RNA surveillance.  |  Hillman, RT., et al. 2004. Genome Biol. 5: R8. PMID: 14759258
4. A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.  |  Lim, J., et al. 2006. Cell. 125: 801-14. PMID: 16713569
5. Potentiation of Smad-mediated transcriptional activation by the RNA-binding protein RBPMS.  |  Sun, Y., et al. 2006. Nucleic Acids Res. 34: 6314-26. PMID: 17099224
6. Loss of 13q is associated with genes involved in cell cycle and proliferation in dedifferentiated hepatocellular carcinoma.  |  Skawran, B., et al. 2008. Mod Pathol. 21: 1479-89. PMID: 18820673
7. LncRNA RBPMS-AS1 promotes NRGN transcription to enhance the radiosensitivity of glioblastoma through the microRNA-301a-3p/CAMTA1 axis.  |  Li, W., et al. 2022. Transl Oncol. 15: 101282. PMID: 34800915
8. Reduced RBPMS Levels Promote Cell Proliferation and Decrease Cisplatin Sensitivity in Ovarian Cancer Cells.  |  Rabelo-Fernández, RJ., et al. 2022. Int J Mol Sci. 23: PMID: 35008958
9. RBPMS is an RNA-binding protein that mediates cardiomyocyte binucleation and cardiovascular development.  |  Gan, P., et al. 2022. Dev Cell. 57: 959-973.e7. PMID: 35472321
10. RBPMS regulates cardiomyocyte contraction and cardiac function through RNA alternative splicing.  |  Gan, P., et al. 2024. Cardiovasc Res. 120: 56-68. PMID: 37890031
11. The RNA-binding protein RBPMS inhibits smooth muscle cell-driven vascular remodeling in atherosclerosis and vascular injury.  |  Du, J., et al. 2025. Proc Natl Acad Sci U S A. 122: e2415933122. PMID: 39999164
12. A unique human gene that spans over 230 kb in the human chromosome 8p11-12 and codes multiple family proteins sharing RNA-binding motifs.  |  Shimamoto, A., et al. 1996. Proc Natl Acad Sci U S A. 93: 10913-7. PMID: 8855282

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-RBPMS Antibody (1C12) has 6 citations in a variety of scientific publications.

Primary antibodies like Anti-RBPMS Antibody (1C12) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

RBPMS Antibody (1C12) Specifications

Alternate Product Name: RBPMS

Product Clone Name: 1C12

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 1-219

Epitope Target: RBPMS

Epitope Species: human

Product Reactivity/Detection: RBPMS

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 100 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 6 citations in various scientific publications

Available Conjugates/Forms for RBPMS Antibody (1C12): N/A