RBM9 Antibody (E-10): sc-271406
- RBM9 Antibody (E-10) is a mouse monoclonal IgG2b κ provided at 200 µg/ml
- raised against amino acids 46-120 mapping near the N-terminus of RBM9 of human origin
- recommended for detection of RBM9 of mouse, rat and human origin by WB, IP, IF and ELISA
- m-IgG2b BP-HRP is the preferred secondary detection reagent for RBM9 Antibody (E-10) for WB applications. This reagent is now offered in a bundle with RBM9 Antibody (E-10) (see ordering information below).
RBM9 Antibody (E-10) is a mouse monoclonal IgG2b antibody that detects RBM9 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). RBM9, also known as RNA binding motif protein 9, RTA, fxh, FOX2, Fox-2, HNRBP2, or HRNBP2, is a 390 amino acid protein characterized by the presence of one RNA recognition motif (RRM) domain, which is crucial for regulating alternative exon splicing, particularly in the nervous system and various other cell types. RBM9′s ability to modulate splicing is vital for generating diverse protein isoforms, allowing for tissue-specific expression and functional variation. RBM9 achieves this by preventing U2AF65 binding, a key component of the spliceosome, to the 3′ splice site of RNA splicing elements, thereby influencing tissue-specific exon splicing. Additionally, RBM9 interacts with estrogen receptor alpha (ERα) transcription factor, further underscoring RBM9′s importance in gene regulation and cellular signaling pathways. Notably, RBM9 exists in eight isoforms due to alternative splicing events, highlighting the complexity and versatility of RBM9′s function in cellular processes.
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RBM9 Antibody (E-10) References:
- RGS proteins: lessons from the RGS9 subfamily. | Cowan, CW., et al. 2001. Prog Nucleic Acid Res Mol Biol. 65: 341-59. PMID: 11008492
- RGS9-1 phosphorylation and Ca2+. | Wensel, TG. 2002. Adv Exp Med Biol. 514: 125-9. PMID: 12596919
- RGS9 modulates dopamine signaling in the basal ganglia. | Rahman, Z., et al. 2003. Neuron. 38: 941-52. PMID: 12818179
- RGS9-2 is a negative modulator of mu-opioid receptor function. | Psifogeorgou, K., et al. 2007. J Neurochem. 103: 617-25. PMID: 17725581
- RGS9-2 negatively modulates L-3,4-dihydroxyphenylalanine-induced dyskinesia in experimental Parkinson's disease. | Gold, SJ., et al. 2007. J Neurosci. 27: 14338-48. PMID: 18160641
- RGS9 concentration matters in rod phototransduction. | Burns, ME. and Pugh, EN. 2009. Biophys J. 97: 1538-47. PMID: 19751658
- Biology and functions of the RGS9 isoforms. | Martemyanov, KA. and Arshavsky, VY. 2009. Prog Mol Biol Transl Sci. 86: 205-27. PMID: 20374717
- RGS9-2 modulates sensory and mood related symptoms of neuropathic pain. | Terzi, D., et al. 2014. Neurobiol Learn Mem. 115: 43-8. PMID: 25150149
- RGS9-2 Modulates Responses to Oxycodone in Pain-Free and Chronic Pain States. | Gaspari, S., et al. 2017. Neuropsychopharmacology. 42: 1548-1556. PMID: 28074831
- RGS9-2 rescues dopamine D2 receptor levels and signaling in DYT1 dystonia mouse models. | Bonsi, P., et al. 2019. EMBO Mol Med. 11: PMID: 30552094
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
RBM9 Antibody (E-10) | sc-271406 | 200 µg/ml | $322.00 | |||
RBM9 Antibody (E-10): m-IgG2b BP-HRP Bundle | sc-548539 | 200 µg Ab; 10 µg BP | $361.00 |