RBM25 Antibody (H-4): sc-374271
- RBM25 Antibody (H-4) is a mouse monoclonal IgG2b κ RBM25 antibody, cited in 3 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 147-185 within an internal region of RBM25 of human origin
- RBM25 Antibody (H-4) is recommended for detection of RBM25 of mouse, rat, human and origin by WB, IP, IF and ELISA; also reactive with additional species, including and equine, canine, bovine, porcine and avian
- Anti-RBM25 Antibody (H-4) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for RBM25 Antibody (H-4) for WB applications. These reagents are now offered in bundles with RBM25 Antibody (H-4) (see ordering information below).
RBM25 Antibody (H-4) is a mouse monoclonal IgG2b kappa light chain antibody that detects RBM25 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). RBM25 (H-4) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. RBM25, also known as RNA binding motif protein 25, S164, RNPC7, RED120, or fSAP94, is a 784 amino acid protein characterized by the presence of one PWI domain and one RNA recognition motif (RRM) domain. RBM25 is primarily localized in the cytoplasm and nuclear speckles, where RBM25 plays a crucial role as a splicing factor, stabilizing the pre-mRNA-U1 small nuclear ribonucleoprotein complex and potentially linking splicing with mRNA 3′-end formation. The importance of RBM25 in mRNA processing highlights potential implications in gene expression regulation and cellular function. The gene encoding RBM25 is located on human chromosome 14, a region that contains over 700 genes and is associated with various genetic disorders, including Alzheimer′s disease and α1-antitrypsin deficiency, underscoring the significance of RBM25 in both normal physiology and disease states.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
RBM25 Antibody (H-4) References:
- A presenilin 1 R278I mutation presenting with language impairment. | Godbolt, AK., et al. 2004. Neurology. 63: 1702-4. PMID: 15534260
- Pathological and physiological functions of presenilins. | Vetrivel, KS., et al. 2006. Mol Neurodegener. 1: 4. PMID: 16930451
- Presenilin-1 mutation E318G and familial Alzheimer's disease in the Italian population. | Albani, D., et al. 2007. Neurobiol Aging. 28: 1682-8. PMID: 16952411
- Identification and characterization of RED120: a conserved PWI domain protein with links to splicing and 3'-end formation. | Fortes, P., et al. 2007. FEBS Lett. 581: 3087-97. PMID: 17560998
- The genetics of very early onset Alzheimer disease. | Filley, CM., et al. 2007. Cogn Behav Neurol. 20: 149-56. PMID: 17846513
- Alpha1-antitrypsin deficiency: current perspective on research, diagnosis, and management. | Stolk, J., et al. 2006. Int J Chron Obstruct Pulmon Dis. 1: 151-60. PMID: 18046892
- Novel splicing factor RBM25 modulates Bcl-x pre-mRNA 5' splice site selection. | Zhou, A., et al. 2008. Mol Cell Biol. 28: 5924-36. PMID: 18663000
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
RBM25 Antibody (H-4) | sc-374271 | 200 µg/ml | $322.00 | |||
RBM25 Antibody (H-4): m-IgG Fc BP-HRP Bundle | sc-529708 | 200 µg Ab; 10 µg BP | $361.00 | |||
RBM25 Antibody (H-4): m-IgGκ BP-HRP Bundle | sc-522683 | 200 µg Ab, 40 µg BP | $361.00 | |||
RBM25 Antibody (H-4) AC | sc-374271 AC | 500 µg/ml, 25% agarose | $424.00 | |||
RBM25 Antibody (H-4) HRP | sc-374271 HRP | 200 µg/ml | $322.00 | |||
RBM25 Antibody (H-4) FITC | sc-374271 FITC | 200 µg/ml | $336.00 | |||
RBM25 Antibody (H-4) PE | sc-374271 PE | 200 µg/ml | $349.00 | |||
RBM25 Antibody (H-4) Alexa Fluor® 488 | sc-374271 AF488 | 200 µg/ml | $364.00 | |||
RBM25 Antibody (H-4) Alexa Fluor® 546 | sc-374271 AF546 | 200 µg/ml | $364.00 | |||
RBM25 Antibody (H-4) Alexa Fluor® 594 | sc-374271 AF594 | 200 µg/ml | $364.00 | |||
RBM25 Antibody (H-4) Alexa Fluor® 647 | sc-374271 AF647 | 200 µg/ml | $364.00 | |||
RBM25 Antibody (H-4) Alexa Fluor® 680 | sc-374271 AF680 | 200 µg/ml | $364.00 | |||
RBM25 Antibody (H-4) Alexa Fluor® 790 | sc-374271 AF790 | 200 µg/ml | $364.00 | |||
RBM25 (H-4) Neutralizing Peptide | sc-374271 P | 100 µg/0.5 ml | $69.00 |