RasGRP3 Antibody (C-8): sc-377488
- RasGRP3 Antibody (C-8) is a mouse monoclonal IgG2a κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 553-589 near the C-terminus of RasGRP3 of human origin
- recommended for detection of RasGRP3 of mouse, rat and human origin by WB, IP, IF and ELISA
- m-IgG Fc BP-HRP and m-IgG2a BP-HRP are the preferred secondary detection reagents for RasGRP3 Antibody (C-8) for WB applications. These reagents are now offered in bundles with RasGRP3 Antibody (C-8) (see ordering information below).
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SEE ALSO...
RasGRP3 Antibody (C-8) is a mouse monoclonal IgG2a antibody that detects RasGRP3 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). RasGRP3 plays a crucial role in cellular signaling as a guanine nucleotide exchange factor, facilitating the activation of Ras and Rap1 proteins, which are pivotal in regulating various cellular processes, including growth, differentiation, and survival. RasGRP3 is primarily located in the cytoplasm and is recruited to the plasma membrane upon activation, where RasGRP3 interacts with diacylglycerol and calcium, leading to the activation of downstream signaling pathways. This localization enables RasGRP3 to act as a critical mediator between cell surface receptors and the Ras signaling cascade, influencing cellular responses to external stimuli. RasGRP3 is highly expressed in heart, brain, lung, and kidney tissues, indicating an essential role in these organs′ physiological functions. Additionally, RasGRP3′s involvement in prostate cancer cell lines highlights potential as a therapeutic target, making anti-RasGRP3 antibody (C-8) an invaluable tool for researchers studying signal transduction and cancer biology.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
RasGRP3 Antibody (C-8) | sc-377488 | 200 µg/ml | $322.00 | |||
RasGRP3 Antibody (C-8): m-IgG Fc BP-HRP Bundle | sc-540728 | 200 µg Ab; 10 µg BP | $361.00 | |||
RasGRP3 Antibody (C-8): m-IgG2a BP-HRP Bundle | sc-546950 | 200 µg Ab; 10 µg BP | $361.00 | |||
RasGRP3 (C-8) Neutralizing Peptide | sc-377488 P | 100 µg/0.5 ml | $69.00 |