RARα/Retinoic Acid Receptor α Antibody (C-1): sc-515796

RARα Antibody (C-1) is a mouse monoclonal IgG1 kappa light chain antibody specifically designed to detect the retinoic acid receptor alpha (RARα), also known as RARA or NR1B1. RARα monoclonal antibody (C-1) targets an internal epitope spanning amino acids 63-362 of the human RARα protein, ensuring precise and reliable binding across multiple species, including mouse, rat, and human. RARα is a crucial nuclear transcription factor located within the cell nucleus, where RARα mediates the effects of retinoic acid, a vital metabolite of vitamin A essential for regulating gene expression involved in cell differentiation, proliferation, and apoptosis. The proper functioning of RARα is imperative for vertebrate development and maintaining tissue homeostasis, and RARα dysregulation is closely associated with various diseases, notably acute promyelocytic leukemia (APL). In APL, a chromosomal translocation fuses the RARα gene with the PML gene, resulting in the oncogenic PML/RARα fusion protein that disrupts normal apoptotic pathways and halts myeloid differentiation. RARα (C-1) antibody performs effectively in western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). This makes anti-RARα antibody (C-1) an indispensable tool for researchers studying RARα signaling pathways and its role in disease mechanisms.

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RARα/Retinoic Acid Receptor α Antibody (C-1) References:

1. Current issues in the management of acute promyelocytic leukemia.  |  Slack, JL. and Rusiniak, ME. 2000. Ann Hematol. 79: 227-38. PMID: 10870476
2. Retinoic acid induces the degradation of the leukemogenic protein encoded by the promyelocytic leukemia gene fused to the retinoic acid receptor alpha gene.  |  Wolf, G. and Smas, CM. 2000. Nutr Rev. 58: 211-4. PMID: 10941258
3. Mechanisms of all-trans retinoic acid-induced differentiation of acute promyelocytic leukemia cells.  |  Zhang, JW., et al. 2000. J Biosci. 25: 275-84. PMID: 11022230
4. Acute promyelocytic leukemia (AML-M3)--Part 2: Molecular defect, DNA diagnosis, and proposed models of leukemogenesis and differentiation therapy.  |  Randolph, TR. 2000. Clin Lab Sci. 13: 106-16. PMID: 11066449
5. Regulation of lipid and lipoprotein metabolism by retinoids.  |  Staels, B. 2001. J Am Acad Dermatol. 45: S158-67. PMID: 11606948
6. The Drosophila EcR gene encodes an ecdysone receptor, a new member of the steroid receptor superfamily.  |  Koelle, MR., et al. 1991. Cell. 67: 59-77. PMID: 1913820
7. Retinoic acid receptor-α regulates synthetic events in human platelets.  |  Schwertz, H., et al. 2017. J Thromb Haemost. 15: 2408-2418. PMID: 28981191
8. Tissue expression of retinoic acid receptor alpha and CRABP2 in metastatic nephroblastomas.  |  Percicote, AP., et al. 2018. Diagn Pathol. 13: 9. PMID: 29378601
9. Investigation of selective retinoic acid receptor alpha antagonist ER-50891 and related analogs for male contraception.  |  Kyzer, JL., et al. 2023. Arch Pharm (Weinheim). 356: e2300031. PMID: 37154197
10. Phosphorylation enhances the target gene sequence-dependent dimerization of thyroid hormone receptor with retinoid X receptor.  |  Bhat, MK., et al. 1994. Proc Natl Acad Sci U S A. 91: 7927-31. PMID: 8058736
11. [Genetic control of the development by retinoic acid].  |  Mark, M., et al. 1997. C R Seances Soc Biol Fil. 191: 77-90. PMID: 9181129
12. Roles of retinoids and their nuclear receptors in the development and prevention of upper aerodigestive tract cancers.  |  Lotan, R. 1997. Environ Health Perspect. 105 Suppl 4: 985-8. PMID: 9255592

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-RARα/Retinoic Acid Receptor α Antibody (C-1) has 25 citations in a variety of scientific publications.

Primary antibodies like Anti-RARα/Retinoic Acid Receptor α Antibody (C-1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

RARα/Retinoic Acid Receptor α Antibody (C-1) Specifications

Alternate Product Name: RARα

Product Clone Name: C-1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 63-362

Epitope Target: RARα

Epitope Species: human

Product Reactivity/Detection: RARα

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 25 citations in various scientific publications

Available Conjugates/Forms for RARα/Retinoic Acid Receptor α Antibody (C-1): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin