RAGE Antibody (RD9C 2): sc-33662

RAGE Antibody (RD9C 2) is a mouse monoclonal IgG1 kappa light chain antibody specifically designed to target the receptor for advanced glycation end products (RAGE), recognizing a peptide corresponding to amino acids 23-54 of bovine RAGE. RAGE is a crucial type I membrane protein expressed on the surface of endothelial cells, mononuclear phagocytes, and vascular smooth muscle cells, where RAGE plays a significant role in mediating cellular responses to advanced glycation end products (AGEs). The interaction between AGEs and RAGE triggers the induction of cellular oxidative stress and activates the transcription factor NF-κB, leading to the activation of intracellular signaling cascades such as p21 Ras and MAP kinase pathways. These processes are fundamental in the regulation of inflammation, vascular dysfunction, and the progression of various diseases, including diabetes, vascular disorders, and amyloidosis. Anti-RAGE antibody (RD9C 2) demonstrates robust reactivity with RAGE from multiple species, including mouse, rat, and human, across applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF), and is also effective with additional species like bovine. This versatility makes RAGE monoclonal antibody (RD9C 2) an essential tool for researchers studying the pivotal functions of RAGE in cellular signaling and disease mechanisms, facilitating advancements in understanding and potentially targeting RAGE-related pathways for therapeutic interventions.

The preferred RAGE antibody is RAGE Antibody (A-9): sc-365154.