Raf-1 Antibody (C-10): sc-373722
- Raf-1 Antibody (C-10) is a mouse monoclonal IgG1 κ, cited in 6 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 621-655 near the C-terminus of Raf-1 of human origin
- recommended for detection of Raf-1 p74 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA; also reactive with additional species, including and equine, canine and bovine
- See Raf-1 (E-10): sc-7267 for Raf-1 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Raf-1 Antibody (C-10) for WB and IHC(P) applications. These reagents are now offered in bundles with Raf-1 Antibody (C-10) (see ordering information below).
Raf-1 Antibody (C-10) is a mouse monoclonal IgG1 antibody that detects Raf-1 in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Raf-1 is a crucial serine/threonine protein kinase that plays a significant role in the regulation of cell signaling pathways, particularly in cell growth and differentiation. Located primarily in the cytoplasm, Raf-1 is activated by receptor tyrosine kinases and transmits signals from these receptors to downstream effectors, such as the MAPK/ERK pathway. This pathway drives various cellular processes, including proliferation and survival, making Raf-1 a key player in oncogenic signaling. Raf-1′s activity is controlled by its N-terminal domain, which suppresses kinase activity under normal conditions, preventing uncontrolled cell growth. Upon activation, Raf-1 triggers significant cellular responses, and dysregulation has been linked to various cancers. Anti-Raf-1 antibody (C-10) provides researchers with a reliable tool for studying Raf-1 dynamics in different biological contexts, enhancing understanding of its role in health and disease.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Raf-1 Antibody (C-10) | sc-373722 | 200 µg/ml | $322.00 | |||
Raf-1 Antibody (C-10): m-IgG Fc BP-HRP Bundle | sc-537867 | 200 µg Ab; 10 µg BP | $361.00 | |||
Raf-1 Antibody (C-10): m-IgGκ BP-HRP Bundle | sc-535301 | 200 µg Ab; 40 µg BP | $361.00 | |||
Raf-1 Antibody (C-10): m-IgG1 BP-HRP Bundle | sc-545415 | 200 µg Ab; 20 µg BP | $361.00 | |||
Raf-1 (C-10) Neutralizing Peptide | sc-373722 P | 100 µg/0.5 ml | $69.00 |